[Study on the pharmacokinetics Oxytropis falcate total flavonoids ointment in rats].

OBJECTIVE

To study the pharmacokinetics of Oxytropis falcate total flavonoids ointment after transdermal administration in rats.

METHODS

The content of 2',4'-dihydroxychalcone (TFC) in plasma was determined by high performance liquid chromatography. The concentration was determined at various time and the data was processed by 3P97.

RESULTS

TFC behaved as a one-compartment and a two-compartment model after transdermal administration of total Oxytropis falcate total flavonoids ointment and solution, respectively. And the C(max) of ointment was improved about 3 times compared with that of the solution.

CONCLUSIONS

The results show that the ointment possesses sustained release property and significantly prolong the degradation half life of TFC. The ointment is benefit to improve the analgesic and anti-inflammatory activity after transdermal administration.