[The pharmacological properties of a direct-action anticoagulant from the herb Nonea poulla (L.) D. C].
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Abstrakt
Nondialyzed fraction of the ammonia extract from Siberian grass Nonea poulla is studied. A stable hypocoagulemy (without cumulative activity) was found in the experiments in vitro and in vivo carried out on rats (intravenous administration of the extract). The LD50 was 150 mg/kg at the effective dose of 10 mg/kg. Intraperitoneal and intramuscular administration during 20 days exerted neither hypocoagulemic nor toxic effect on the haemopoesis system and did not change the body weight of the animals.