Chlorogenic acid ameliorates obesity by preventing energy balance shift in high fat diet induced obese mice

Background: chlorogenic acid is a type of phenolic acid found in many plants. Chlorogenic acid has anti-obesity effect with unclear mechanism. The current study was to investigate the regulatory effect of chlorogenic acid on energy balance in high fat diet induced obese C57BL/6J mice administrated with 100 mg/kg chlorogenic acid for 13 weeks.

Results: consumption of chlorogenic acid ameliorated high fat diet induced obesity. Chlorogenic acid did not change the physical activity but significantly decreased food intake and increased body temperature, thermal dissipation and brown adipose tissue activity. Moreover, chlorogenic acid improved glucose tolerance but had moderate impact on other blood indices. Additionally, chlorogenic acid failed to restore the microbiota change associated with high fat diet induced obesity, but modified the gut bacterial composition in a unique way.

Conclusion: supplementation with chlorogenic acid can improve the high fat induced obesity and associated glucose intolerance mainly via regulating food intake and energy expenditure. This article is protected by copyright. All rights reserved.

Keywords: chlorogenic acid; energy expenditure; gut microbiota; intake; obesity.