received the standard ALP treatment according to TUPTC protocol as follows: patient resuscitation, care of airway, breathing and circulation, gastric decontamination with 2 ampoules sodium bicarbonate (each ampoule 25 ml containing 2.1 gm sodium bicarbonate) followed by activated charcoal in dose of 1 g/Kg orally, adequate hydration, normal saline administration (0.9% Sodium Chloride IV), vasopressors IV infusions, inhalation of 100% oxygen, ranitidine IV, magnesium sulfate IV infusion and other supportive treatment.

Patients will start therapy with Hydroxyethyl starch instead of normal saline (6% hetastarch 600/0.75 in 0.9% sodium chloride) with a dose of 500 cc in 6 hours. Additionally, patient will receive the standard ALP treatment according to TUPTC protocol in the same order of placebo.

Patients will start therapy with combined Hydroxyethyl starch (Voluven®, fresenius kabi, Germany) and hydrocortisone (SOLU-CORTEF 100 mg ampoule) instead of normal saline of normal saline as follow: Hydroxyethyl starch dose is 6% hetastarch 600/0.75 in 0.9% sodium chloride with a dose of 500 cc in 6 hours. Hydrocortisone dose is 200-300 mg /day intravenously until normalization of blood pressure. Additionally, patient will receive the standard ALP treatment according to TUPTC protocol in the same order of placebo.

Potential Therapeutic Role

Hydroxyethyl starch dose is 500 cc in 6 hours

Hydroxyethyl Starch 130-0.4 60 MG/ML [Voluven]

Hydrocortisone dose is 200-300 mg /day intravenously

Hydrocortisone

Placebo

Tarek Abdel Hay

The Potential Therapeutic Role of Hydroxyethyl Starch and Hydrocortisone in Acute Aluminum Phosphide Poisoning

The Potential Therapeutic Role of Hydroxyethyl Starch and Hydrocortisone in Acute Aluminum Phosphide Poisoning: A Randamized Controlled Clinical Trial

incidence of need for intubation and mechanical ventilation for each patient

the incidence of need for ICU admission for each patient

tarek abdel hay mostafa

principle investigator

Tanta University

10 patients with NDMs onychomycosis treated with amphotericin B in 30% DMSO.

10 patients with NDMs onychomycosis treated with 30% DMSO.

Fungal Infection

Onychomycosis

Fungus, Nail

amphotericin B in 30% DMSO was given to patients in active comparators group for continuous 12 weeks.

amphotericin B in 30% DMSO

30% DMSO was given to patients in placebo comparators group for continuous 12 weeks.

30% DMSO

Department of Dermatology Siriraj Hospital

Topical Amphotericin B in 30% Dimethylsulphoxide in Treating of Non-dermatophytes Onychomycosis

Comparison of Effectiveness of Topical Amphotericin B in 30% Dimethylsulphoxide and 30% Dimethylsulphoxide in Treating of Non-dermatophytes Onychomycosis: Randomized Double Blind Controlled Trial Pilot Study

Effectiveness was evaluated by patients who had negative on mycological laboratory (mycological cure) as percentage.

Median time to mycological cure were defined as time (days, months or years) that had negative on mycological laboratory

Clinical cure was defined as the patients had complete clinical improvement or having <10% nail involvement.

Median time to clinical cure were defined as time (days, months or years) that had clinical improvement of the affected nails.

Side effects was assessed by the percentage of patients developed any side effect such as erythema, burning sensation, pain.

Mahidol University

Randomized double blind controlled trial pilot study

Double blind controlled trial between participants, drug preparing team, doctors, investigators, and outcome assessors.

In this group, the patients received 100mg ferrous succinate and 200mg vitamin C three times per day for 3-4 months

In this group, the patients received 100mg ferrous succinate three times per day for 3-4 months

In this group, the patients received 200mg ferrous succinate three times per day for 3-4 months

Anemia, Iron-Deficiency

As experimental group, when patients take the tablets of ferrous succinate, they also take vitamin C at the same time

ferrous succinate and vitamin C

As active comparator, patients take the tablets of ferrous succinate with normal dosage in clinical practice

ferrous succinate

As another active comparator, patients take the tablets of ferrous succinate with double dosage

Hushan Hospital

the Efficacy and Safety of Vitamin C for Iron Supplementation in Adult IDA Patients

The Efficacy and Safety of Vitamin C for Iron Supplementation Therapy in Adult Patients With Iron Deficiency Anemia(IDA)

The increased levels of hemoglobin after receiving three different treatment regimens are evaluated in the second week

The increased levels of reticulocyte after receiving three different treatment regimens are evaluated in the second week

The increased levels of hemoglobin after receiving three different treatment regimens are evaluated in the fourth week

The increased levels of ferritin after receiving three different treatment regimens are evaluated in the eighth week

The incidence of adverse events every two weeks are assessed, the adverse events include bellyache, diarrhea, constipation, vomiting, nausea.

aluminum/erbrechen

The Potential Therapeutic Role of Hydroxyethyl Starch and Hydrocortisone in Acute Aluminum Phosphide Poisoning

Topical Amphotericin B in 30% Dimethylsulphoxide in Treating of Non-dermatophytes Onychomycosis

the Efficacy and Safety of Vitamin C for Iron Supplementation in Adult IDA Patients

Die vollständigste Datenbank für Heilkräuter, die von der Wissenschaft unterstützt wird