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Aminophylline therapy does not improve outcome and increases adverse effects in children hospitalized with acute asthmatic exacerbations.

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OBJECTIVE To evaluate the effects of aminophylline (Am) in children hospitalized with asthma. METHODS Prospective, randomized, double-blind, placebo-controlled trial. Subjects were children between the ages of 5 and 18 years admitted for asthma exacerbation to either a tertiary care children's

Aminophylline for acute exacerbations of chronic obstructive pulmonary disease. A controlled trial.

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OBJECTIVE To determine the efficacy of intravenous aminophylline in the treatment of patients hospitalized for exacerbation of chronic obstructive pulmonary disease. METHODS Randomized, double-blind, placebo-controlled trial during the first 72 hours of hospitalization. METHODS Thirty patients

[Chronic asthma in children: comparison between a delayed-action theophylline preparation and a prompt-release aminophylline preparation].

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Data from 34 patients were included in the analysis of this open group comparative study comparing a controlled release theophylline given twice daily with immediate release aminophylline given four times daily. The treatment period was of eight weeks duration. There was no significant difference

Aminophylline dosage in acute severe asthma.

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In 27 cases of acute severe asthma, a loading dose of 5 mg/kg of aminophylline (omitted if already receiving oral theophylline) followed by a continuous infusion of 1 mg/kg per hour gave satisfactory theophylline levels at 4 h and 24 h. Theophylline clearance rates varied widely, vomiting was

Use of a pharmacokinetic method for establishing doses of aminophylline to treat acute bronchospasm.

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A pharmacokinetic method of establishing individualized doses of aminophylline in patients with acute bronchospasm was evaluated. Patients admitted to a hospital who required intravenous aminophylline for bronchodilation were studied. Blood samples were drawn before treatment for

Intravenous aminophylline for acute severe asthma in children over 2 years using inhaled bronchodilators.

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BACKGROUND Intravenous aminophylline was the bronchodilator of choice for many years until supplanted by more effective bronchodilators in the treatment of acute paediatric asthma. Recently there has been renewed interest in this therapy for children with acute severe asthma. OBJECTIVE To determine

Immediate care after aspiration of vomit.

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The diagnosis of aspiration can be made from the characteristic clinical features. Management is then based on the measurement of the pH of the gastric contents, blood gases and acid-base values, the serial measurement of pulse blood pressure and central venous pressure, and the haemoglobin and

Aminophylline in the treatment of acute asthma when beta 2-adrenergics and steroids are provided.

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BACKGROUND The purpose of this study was to test the contribution of aminophylline in improving peak expiratory flow rate (PEFR) during emergency department treatment of acute asthma when metaproterenol sulfate and steroid therapy are also provided. METHODS In a prospective, randomized,

Addition of intravenous aminophylline to beta2-agonists in adults with acute asthma.

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BACKGROUND Aminophylline has been used extensively in acute asthma, but its role is unclear especially with respect to any additional benefit when added to beta2-agonists. OBJECTIVE To determine the magnitude of effect of the addition of intravenous aminophylline to beta2-agonists in adult patients

The current role of intravenous aminophylline in acute paediatric asthma.

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Intravenous aminophylline is effective in children with acute asthma and was the bronchodilator of choice for many years. However, with the advent of inhaled b agonists and anticholinergic agents an alternative, less invasive, therapeutic strategy is currently available. If children with acute

Addition of intravenous aminophylline to inhaled beta(2)-agonists in adults with acute asthma.

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BACKGROUND Asthma is a chronic condition in which sufferers may have occasional or frequent exacerbations resulting in visits to the emergency department (ED). Aminophylline has been used extensively to treat exacerbations in acute asthma settings; however, it's role is unclear especially with

Intravenous aminophylline for acute severe asthma in children over two years receiving inhaled bronchodilators.

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BACKGROUND Since the advent of inhaled beta2-agonists, anticholinergic agents and glucocorticoids, the role of aminophylline in paediatric acute asthma has become less clear. There remains some consensus that it is beneficial in children with acute severe asthma, receiving maximised therapy (oxygen,

Randomised comparison of intravenous magnesium sulphate, terbutaline and aminophylline for children with acute severe asthma.

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OBJECTIVE This study compared the efficacy of intravenous magnesium sulphate, terbutaline and aminophylline for children with acute, severe asthma poorly responsive to standard initial treatment. METHODS We enrolled 100 children, aged one to 12 years, who had failed to respond to initial standard

Intravenous beta(2)-agonists versus intravenous aminophylline for acute asthma.

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BACKGROUND Inhaled beta(2)-agonist therapy is central to the management of acute asthma. For rapid bronchodilation in severe cases, penetration of inhaled drug to the affected small conducting airway may be impeded, and the intravenous (IV) rather than inhaled administration of bronchodilators may

Theophylline and antiparasitic drug interactions. A case report and study of the influence of thiabendazole and mebendazole on theophylline pharmacokinetics in adults.

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To determine a change in theophylline pharmacokinetics during concomitant thiabendazole or mebendazole therapy, we studied six normal, healthy male volunteers. Aminophylline was administered intravenously, followed by a 30-h blood sampling period. Subjects were randomized to receive thiabendazole or

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