Melatonin (N-acetyl-5-methoxytryptamine) 25 mg oral administration 1 hour before bedtime for 12 weeks.

Comparable placebo pill, oral administration 1 hour before bedtime for 12 weeks.

Depression

Acute Coronary Syndrome

Melatonin (N-acetyl-5-methoxytryptamine)

Placebo

Roskilde and Køge Hospital, Department of Surgery.

Department of internal Medicin, Holbaek Sygehus

Department of Cardiology, Roskilde Sygehus

Department of internal medicin, M5

Department of Cardiology, Hvidovre Hospital,

Department of Cardiology, Slagelse Sygehus

The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome

MDI is a self-rating depression scale with 12 questions. MDI has previously been investigated in a Danish population. On a six-point Likert scale, the items measure how much time the symptoms have been present during the last 14 days. MDI is scored according to specific guidelines and can be used either as a rating scale or diagnostic instrument. For inclusion the investigators used the diagnostic instrument (depression was an exclusion criteria) and for all other MDI measurements the investigators used the rating scale. Diagnostic scale using the ICD-10 algorithm: Mild depression: 2 core symptoms and 2 other symptoms Moderate depression: 2 core symptoms and 4 other symptoms Severe depression: 3 core symptoms and 5 other symptoms Rating scale: No depression - score from 0-20 Mild depression - score from 21-25 Moderate depression - score from 26-30 Severe depression - score from 31-50

MDI is a self-rating depression scale with 12 questions. Rating scale: No depression - score from 0-20 Mild depression - score from 21-25 Moderate depression - score from 26-30 Severe depression - score from 31-50.

Outcomes measured - Nightime: time in bed, (min)

Outcomes measured - Nightime: total sleep time (min)

Outcomes measured - Nightime: sleep effectiveness (%)

Outcomes measured - Nightime: wake after sleep onset (min)

Outcomes measured - Nightime: sleep latency (min)

Outcomes measured - Nightime: number of awakenings (duration of 5 min).

Outcomes measured - Daytime: Time awake (min)

Outcomes measured - Daytime: time asleep (min)

Outcomes measured - Daytime: number of naps

Outcomes measured: Mesor - Adjusted mean of activity counts over 24 hours.

Outcomes measured: Acrophase - Time of peak amplitude.

Outcomes measured: Amplitude - Peak activity value above mesor.

Outcomes measured: F-statistics - Goodness of fit of general cosine model in summarizing the actual data.

Outcomes measured: Inter-daily Stability - The regularity of the rhythm from one day to next.

Outcomes measured: Intra-daily Variability - Fragmentation of the rhythm.

The HADS consists two subscales; one for anxiety (HADS-A) and one for depression (HADS-D), which can be used separately. Each scale consists of 7 questions which are graded on a 4 point scale (0-1-2-3) and is summed into a total score between 0-21. A score of 7 or lower is negative case, a score of 8 - 10 is a doubtful case, and a score of 11 or above is a positive case. The scale inquires about the presence of symptoms during the last week and, hence, should be administered at a maximum of weekly intervals].

The PSQI, which asses sleep quality during the last 4 weeks, and has a clinical established cut of 5 ≥ as poor sleeper and 8≥ as having sleep problems needing treatment

A sleep diary is the patient's own account of sleep data, and they are asked to fill in a diary page each morning after awakening.

The UKU has been develop for use to monitor side effect of psychotropic drugs, and has been validated in several Nordic countries. The UKU consists of a single symptom rating scale (48 items), a global assessment of influence of side effect on patients daily lives (patient and doctor), and the side effect influence on continued medication treatment.

Anxiety measured by VAS (visual analog scale). A subjective feeling of anxiety was registered on a VAS going from "no anxiety", equivalent to 0mm to "worst possible anxiety", equivalent to 100mm.

Fatigue measured by VAS (visual analog scale). A subjective feeling of Fatigue was registered on a VAS going from "no Fatigue", equivalent to 0 mm to "worst possible Fatigue", equivalent to 100mm.

Pain measured by VAS (visual analog scale). A subjective feeling of Pain was registered on a VAS going from "no Pain", equivalent to 0 mm to "worst possible Pain", equivalent to 100mm.

Sleep Quality measured by VAS (visual analog scale). A subjective feeling of Sleep Quality was registered on a VAS going from "best possible sleep", equivalent to 0 mm to "worst possible sleep", equivalent to 100mm.

General Well-being measured by VAS (visual analog scale). A subjective feeling of General Well-being was registered on a VAS going from "very high well-being", equivalent to 0 mm to "very low well-being", equivalent to 100mm.

Endothelial function measured by EndoPAT with an outcome measure of reactive hyperemia index (RHI).

The blood will be stored in a biobank for later analysis. A not yet determined panel of MiRNA will be measured.

Blood work, oxidative-stress markers ADMA and Arginine.

Zealand University Hospital

Psychiatric Research Unit, Region Zealand, Denmark

University of Copenhagen

Pharma Nord

Participants in the ASTM group will undergo ASTM training in groups of four .This involves participating in four, 90-120 minutes sessions each of four consecutive days. This will be followed by once weekly 45-60 minute follow up sessions for 12 weeks. In addition participants will be asked to practice ASTM at home for 20 minutes twice daily over the study period (24 weeks). Participants will be asked to log practice frequency and any other noteworthy observations in the log sheet provided to them.

Participants randomized to control arm (TAU) will continue to receive their treatment as usual including antidepressant medications and/or psychotherapy

Major Depressive Disorder

Automatic Self Transcending Meditation

London Health Sciences Centre

Automatic Self Transcending Meditation Versus Treatment as Usual

Automatic Self-transcending Meditation (ASTM) Therapy Versus Treatment as Usual (TAU) in Late Life Depression: Implications for Cardiovascular Health and Cross-fertilization Across Different Levels of Care.

autonomic measure of heart rate variability will be assessed at baseline as well as at end of intervention (week 12).

Change in Hamilton 17 item depression rating scale and the geriatric depression scale (GDS).

Change in geriatric anxiety inventory (GAI).

Change in physical activity scale of the elderly (PASE).

Change in quality of life profile seniors version (QOLPS) scale

Akshya Vasudev

Principal Investigator

Lawson Health Research Institute

University of Western Ontario, Canada

Renal Guard in addition to Saline and N-Acetylcysteine

Radiographic Contrast Agent Nephropathy

Aortic Valve Stenosis With Insufficiency

Renal Guard

Conventional Treatment

Tel Aviv Medical Center

The Effect of the Forced Diuresis With Matched Hydration in Reducing Acute Kidney Injury During TAVI

Reducing Acute Kidney Injury in TAVI Patients (REDUCE Trial)

we will measure the incidence of VARC-2 acute kidney injury at 48-72 hours.

evaluate whether endothelial dysfunction can predict AKI

we will compare patients with and without statin treatment for the incidence of AKI

We will evaluate the prognostic ability of carotid doppler for predicting AKI

We will evaluate inflammatory, metabolic and neuroendocrine biomarkers

michal roll

VPRD

Tel-Aviv Sourasky Medical Center

Patients with resistant hypertension and chronic kidney disease (GFR between 15 and 60) will receive Renal Denervation as a treatment

Chronic Kidney Disease

The Symplicity Renal Denervation System is indicated for the delivery of low-level radiofrequency energy through the wall of the renal artery to denervate the kidney and reduce blood pressure in adult patients with refractory hypertension. The Symplicity Generator delivers controlled relatively low power radiofrequency energy (approximately 8 watts for 2 minutes). The Symplicity System selectively denervates the kidney by delivering radiofrequency from the generator via the electrode of the catheter through the renal artery wall from the intra-luminal side to ablate the renal sympathetic efferent and afferent nerves and reduce overall sympathetic nervous system activity.

Renal Denervation

Regina Qu'Appelle Health Region

Renal Denervation in Patients With Chronic Kidney Disease

Prairie Renal Denervation Study

measured using ATCOR machine: Augmentation index (%) Augmentation pressure (mm Hg) Central pulse pressure (mm Hg) Central systolic pressure (mm Hg) Central diastolic pressure (mm Hg) Pulse pressure amplification (mm Hg) Time to reflection (Tr) in ms Pulse Wave Velocity

Using an echocardiogram, the following cardiac measures will be taken:
Left ventricle volume Left ventricle hypertrophy Left ventricle function Left atrial mass E-wave velocity E-prime velocity

systolic and diastolic blood pressure (mm Hg) measured using BP-Tru machine.

systolic and diastolic blood pressure (mm Hg) measured using BP-Tru machine

For 24-hour blood pressure, we will record the following:
12-hour daytime Systolic Pressure (mm Hg) 12-hour daytime Diastolic Pressure (mm Hg) 12-hour nighttime Systolic Pressure (mm Hg) 12-hour nighttime Diastolic Pressure (mm Hg)

anxiolytic/infarzierung

The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome

Automatic Self Transcending Meditation Versus Treatment as Usual

The Effect of the Forced Diuresis With Matched Hydration in Reducing Acute Kidney Injury During TAVI

Renal Denervation in Patients With Chronic Kidney Disease

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