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atrial fibrillation/kalium
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12 Ergebnisse
Thieno[3,2-c]pyridine potassium channel inhibitors
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to thienopyridine compounds which are potassium channel inhibitors. Pharmaceutical compositions comprising the compounds and their use in the treatment or prevention of cancer, arrhythmias, autoimmune diseases and
Compounds and their use as IKACh blockers
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TECHNICAL FIELD
The present invention relates to a novel class of compounds which are pharmacologically effective as potassium channel inhibitors, in particular inhibitors of the acetylcholine operated inward rectifying potassium channel current, i.e. IKACh blockers.
The invention also relates to
Indanyl-substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-C]pyridines, their use as medicament, and pharmaceutical preparations comprising them
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This application is a national stage application under 35 U.S.C. .sctn.371 of International Application No. PCT/EP2011/065,713, filed Sep. 12, 2011, the disclosure of which is explicitly incorporated by reference herein.
The invention relates to 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine
Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-C]pyridines, their use as medicament, and pharmaceutical preparations comprising them
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The invention relates to 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine compounds of the formula I,
##STR00002##
The compounds of formula I act on the TASK-1 (KCNK3) potassium channel. The compounds are suitable for the treatment of several pathologies and particularly suitable as antiarrhythmic
Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them
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This application is a national stage application under 35 U.S.C. .sctn.371 of International Application No. PCT/EP2011/066061, filed Sep. 16, 2011, the disclosure of which is explicitly incorporated by reference herein.
The invention relates to 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine compounds
Fused pyrroledicarboxamides and their use as pharmaceuticals
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The present invention relates to fused pyrroledicarboxamides of the formula I,
##STR00002## in which R1 to R9, X, m and n are as defined below. The compounds of the formula I are inhibitors of the acid-sensitive potassium channel TASK-1 and suitable for the treatment of TASK-1 channel-mediated
Fused pyrroledicarboxamides and their use as pharmaceuticals
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This application is a national stage application under 35 U.S.C. .sctn.371 of International Application No. PCT/EP2013/051996, filed Feb. 1, 2013, the disclosure of which is explicitly incorporated by reference herein.
The present invention relates to fused pyrroledicarboxamides of the formula
Indanyl-substituted benzenecarboxamides, processes for their preparation, their use as a medicament, and pharmaceutical formulations containing them
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The invention relates to compounds of formula I ##STR2##
in which R(8) is either a 1-indanyl radical of formula II or a 2-indanyl radical of formula III ##STR3##
and in which R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(9), R(10), R(11), R(12), R(13), R(14), and R(15) have the meanings stated below,
Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use
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DESCRIPTION
The invention relates to compounds of formula I, represented in the structure below, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings as stated below, and to the use thereof, especially in pharmaceuticals.
##STR00002## The present invention encompasses compounds of formula I
Anthranilamides and methods of their use
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The invention relates to compounds of formula I, ##STR00002## in which R(1), R(2), R(3), R(4), R(5), R(6) and R(7) have the meanings indicated hereinafter, to their preparation and use, and in particular, to their use as pharmaceuticals.
The compounds of formula I have not previously been disclosed.
Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use
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This application claims the priority of German application No. 10128331.8, filed on Jun. 12, 2001, under 35 U.S.C. 119, which is incorporated by reference.
DESCRIPTION
The invention relates to compounds of formula I, represented in the structure below, in which R1, R2, R3, R4, R5, R6 and R7 have the
Anthranilamides and methods of their use
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This application is a CON of 10/132,163, filed Apr. 26, 2002.
The invention relates to compounds of formula I,
##STR00002## in which R(1), R(2), R(3), R(4), R(5), R(6) and R(7) have the meanings indicated hereinafter, to their preparation and use, and in particular, to their use as
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