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brain ischemia/hypoxie
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Seite 1 von 25 Ergebnisse
Piperidine compounds for treating anoxia, cerebral ischemia migraine or epilepsy
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The present invention relates to therapeutically active piperidine compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the treatment of anoxia, traumatic injury, ischemia, migraine and epilepsy.
It is well known
Use of N-acetyl-D-glucosamine in the manufacture of pharmaceutical useful for treating cardio-cerebrovascular anoxemia
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TECHNICAL FIELD
The present invention relates to the use of N-acetyl-D-glucosamine and pharmaceutical acceptable salts thereof in the manufacture of a medicament for resisting cardiac and cerebral ischemia as well as oxygen-deficiency.
BACKGROUND ART
The cardiac and cerebral ischemia as well as
Agents for treatment of brain ischemia
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BACKGROUND OF THE INVENTION
This invention pertains to heterocyclic carbon compounds having drug and bio-affecting properties and to their preparation and use. In particular, the invention is concerned with 1,4-disubstituted piperazine derivatives wherein one substituent is a 5-halopyrimidin-2-yl
Treatment of cerebral ischemia
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FIELD OF THE INVENTION
The present invention relates to the field of medicine. It provides new compositions and methods for treating or protecting individuals in need thereof from cerebral ischemia or hypoxia. The invention also relates to new compositions and methods for treating stroke. More
N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
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FIELD OF THE INVENTION
This invention is in the field of medicinal chemistry. In particular, this invention relates to N,N'-disubstituted guanidine analogues, and to compounds and pharmaceutical composition comprising the same, which possess neuroprotective capability. This invention further relates
N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
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FIELD OF THE INVENTION
This invention is in the field of medicinal chemistry. In particular, this invention relates to N,N'-disubstituted guanidine analogues, and to compounds and pharmaceutical composition comprising the same, which possess neuroprotective capability. This invention further relates
Amino acid derivatives of substituted quinoxaline 2,3-dione derivatives as glutamate receptor antagonists
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BACKGROUND OF THE INVENTION
This invention is for novel glutamate receptor antagonists which are new compounds of the 5,6,7,8-substituted quinoxaline 2,3-dione type. The fused ring system is substituted at the a- or b-position by amino acid derivatives. The compounds are active as excitatory amino
Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
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BACKGROUND OF THE INVENTION
This invention is for novel glutamate receptor antagonists which are new compounds of the 5,6,7,8-substituted quinoxaline 2,3-diones type. The fused ring system is substituted at the a- or b-position by amino acid derivatives. The compounds are active as excitatory amino
Substituted quinoxaline-2-ones as glutamate receptor antagonists
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BACKGROUND OF THE INVENTION
This invention is for novel glutamate receptor antagonists which are new compounds of the substituted quinoxaline 2-ones type. The compounds are active as excitatory amino acid receptor antagonists acting at glutamate receptors, including either or both
Sulfonamide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
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BACKGROUND OF THE INVENTION
The present invention concerns novel sulfonamide derivatives of substituted quinoxaline 2,3-diones having utility as glutamate receptor antagonists. The fused ring quinoxaline 2,3-dione system is substituted at the a- or b-position by sulfonamide derivatives. The
Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
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BACKGROUND OF THE INVENTION
This invention is for novel glutamate receptor antagonists which are new compounds of the 5,6,7,8-substituted quinoxaline 2,3-diones type. The fused ring system is substituted at the a or b position by amino acid derivatives. The compounds are active as excitatory amino
Methods for providing neuroprotection for the animal central nervous system against neurodegeneration caused by ischemia
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is directed to methods for preconditioning and/or providing neuroprotection to the animal central nervous system against ischemia, neurodegeneration, trauma and metal poisoning, including associated cognitive, behavioral and
Optically active clausenamides, process of the preparation thereof, pharmaceutical composition containing the same and their medical use
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FIELD OF THE INVENTION
The present invention relates to some new optically active clausenamide derivatives, process of the preparation thereof, a pharmaceutical composition containing the same and their medical use, particularly their use in the respects of hypoxia protective, nootropic and
Compositions having neuroprotective and analgesic activity
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FIELD OF THE INVENTION
This invention involves means for treating neuronal injury and achieving analgesia by administration of compositions containing compounds of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are alkyl having 1-8 carbon atoms.
BACKGROUND OF THE INVENTION
Compounds having an
Compositions having neuroprotective and analgesic activity
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FIELD OF THE INVENTION
This invention involves means for treating neuronal injury and achieving analgesia by administration of compositions containing compounds of the formula: ##STR2##
wherein R.sup.1 and R.sup.2 are alkyl having 1-8 carbon atoms.
BACKGROUND OF THE INVENTION
Compounds having an
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