Isoxazolone compounds having the generic structure: ##STR1##are used to treat disease associated with unwanted cytokine activity, including rheumatoid arthritis, osteoarthritis, diabetes, HIV/AIDS, inflammatory bowel disease, Crohn's disease, ulcerative colitis, congestive heart, hypertension, chronic obstructive pulmonary disease, septic shock syndrome, tuberculosis, adult respiratory distress, asthma, atherosclerosis, muscle degeneration, periodontal disease, cachexia, Reiter's syndrome, gout, acute synovitis, anorexia and bulimia nervosa fever, malaise, myalgia and headaches.

The Procter &amp; Gamble Company

Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity

The present invention relates to compounds of the formula ##STR00001## wherein R.sup.1 and R.sup.1' are each independently hydrogen or methyl and X is --C(O)N(CH.sub.3)-- or --N(CH.sub.3)C(O)--, and to pharmaceutically acceptable acid addition salts thereof for the treatment of numerous inflammatory conditions, migraine, rheumatoid arthritis, asthma, inflammatory bowel disease, mediation of the emetic reflex, Parkinson's disease, anxiety, depression, psychosis, motion sickness, induced vomiting, pain, headache, migraine, Alzheimer's disease, multiple sclerosis, attenuation of morphine withdrawal, cardiovascular changes, oedema, such as oedema caused by thermal injury, chronic inflammatory diseases such as rheumatoid arthritis, asthma/bronchial hyperreactivity and other respiratory diseases including allergic rhinitis, inflammatory diseases of the gut including ulcerative colitis and Crohn's disease, ocular injury and ocular inflammatory diseases, traumatic brain injury, motion sickness, emesis and psychoimmunologic and psychosomatic disorders.

colitis/kopfschmerz

Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity

Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity

Bi-pyridinyl derivatives as NK-1 antagonists

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