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FIELD OF THE INVENTION
The present invention relates to a novel use of diterpene compounds as a therapeutic agent for the treatment of inflammatory disease, immunological disease or cancer.
BACKGROUND OF THE INVENTION
Exposure of human tissue or cells to harmful stimuli such as lipopolysaccharide
TECHNICAL FIELD
The present invention relates to diterpene derivatives and anti-inflammatory analgesic agents comprising the same. More specifically, the present invention relates to diterpene derivatives prepared from the components which are extracted from Acanthopanax Koreanum and represented by
FIELD OF THE INVENTION
The present invention relates generally to a composition exhibiting synergistic inhibition of the expression and/or activity of inducible cyclooxygenase-2 (COX-2). More particularly, the composition comprises, as a first component, a diterpene triepoxide lactone species and,
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to compositions that can be used to treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and/or NF.kappa.B, to methods of modulating inflammation, including in
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to synergistic compositions that treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and to methods of modulating inflammation in cells. More specifically,
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to synergistic compositions that treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and to methods of modulating inflammation in cells. More specifically,
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to compositions that can be used to treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and/or NF.kappa.B, to methods of modulating inflammation, including in
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to compositions that can be used to treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and/or NF.kappa.B, to methods of modulating inflammation, including in
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to compositions that can be used to treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and/or NF.kappa.B, to methods of modulating inflammation, including in
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to synergistic compositions that treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and to methods of modulating inflammation in cells. More specifically,
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to compositions that can be used to treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and/or NF.kappa.B, to methods of modulating inflammation, including in
1. TECHNICAL FIELD
The present invention relates to a series of organic compounds and methods of preparation, in particular relates to an ent-kaurene diterpenoid compound and its derivatives, and extraction and preparation methods and use thereof.
2. BACKGROUND ART
Rabdosia rubescens (Hemls.) Hara
FIELD OF THE INVENTION
The invention relates to chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. The invention also relates to methods of synthesizing
RELATED APPLICATIONS
This application claims priority from Patent Cooperation Treaty Application Serial No. PCT/EP04.00515 (filed 12 May 2004) and from Chile national patent application Serial No. CL 178-2004 (filed 3 Feb. 2004), the contents of which are incorporated here by reference.
UNITED
BACKGROUND OF THE INVENTION
This application is a continuation-in-part of copending U.S. patent application Ser. No. 06/723,214 which was filed on Apr. 15, 1985, now U.S. Pat. No. 4,745,104.
The present invention relates generally to compounds having anti-inflammatory, anti-proliferative and