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12 Ergebnisse
New eudesmane sesquiterpene and other constituents from Artemisia mongolica.
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The aerial parts of Artemisia mongolica afforded the eudesmane derivative ludovicin B, two coumarins, umbelliferone and esculetin, two methoxylated flavones, eupatilin and pectolinarigenin, as well as a new eudesmane sesquiterpene, 6alpha,8alpha-dihydroxyisocostic acid methyl ester. Structures were
Nitric oxide production inhibitory eudesmane-type sesquiterpenoids from Artemisia argyi.
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Six new eudesmane-type sesquiterpene derivatives, artemargyinins A-F ( 1 - 6 ) were isolated from the leaves of Artemisia argyi . Their structures were elucidated based on the extensive analysis of spectroscopic data. Compounds 1 - 6 feature a lactone ring-opening eudesmane-type sesquiterpene with
Three new eudesmanes from Artemisia japonica.
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Three new eudesmanes, named artemisidiols A-C, together with eight known compounds, were isolated from the leaves of Artemisia japonica Thunb. (Asteraceae). Their structures were determined on the basis of spectroscopic data. Although oxygenated eudesmanes frequently occur in Asteraceae plants, the
Synergistic induction of 1,25-dihydroxyvitamin D(3)- and all-trans-retinoic acid-induced differentiation of HL-60 leukemia cells by yomogin, a sesquiterpene lactone from Artemisia princeps.
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Many anti-inflammatory agents are known to significantly enhance the terminal differentiation of some cancer cells such as leukemia cells. In this study, the effect of yomogin, a eudesmane sesquiterpene lactone isolated from Artemisia princeps with anti-inflammatory activity, was investigated in
Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2
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Two new sesquiterpenoids, artemlavanins A (1) and B (3), together with fifteen known compounds (2 and 4-17) were isolated from the EtOH extract of Artemisia lavandulaefolia. The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD
Highly oxygenated sesquiterpenes in Artemisia alba Turra.
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Ten new sesquiterpene alcohols of which seven germacranes, a eudesmane, a guaiane and an oplopane were isolated from the aerial parts of Artemisia alba Turra. Their structures and relative stereochemistry were elucidated by spectral methods ((1)H and (13)C NMR, COSY, HSQC, HMBC, NOESY, and MS). In
New constituents of Artemisia monosperma.
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A new eudesmane sesquiterpene (1) and a C(10) diyne (2) were isolated from the aerial parts of Artemisia monosperma. The structures of these compounds were determined as rel-1beta,3alpha,6beta-trihydroxyeudesm-4-ene (1) and 1,3R,8R-trihydroxydec-9-en-4,6-yne (2) on the basis of spectral data
Structurally diverse sesquiterpenoids from the aerial parts of Artemisia annua (Qinghao) and their striking systemically anti-inflammatory activities
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Thirteen new sesquiterpenoids, arteannoides F-R (1-13), along with 13 known analogues (14-26), were isolated from the dried aerial parts of Artemisia annua L. Their structures, including absolute configurations, were unambiguously determined by a combination of physical data analyses (HRESIMS, 1D
Eudesmanolides and Other Constituents from Artemisia argyi.
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The phytochemical investigation of the aerial parts of ARTEMISIA ARGYI afforded beta-sitosterol, stigmasterol, alpha-amyrin, beta-amyrin, friedelin, naringenin, quercetin, and four eudesmane derivatives, two of which were new eudesmanolides. The structures of the novel compounds were elucidated by
Three new sesquiterpenoids with cytotoxic activity from Artemisia argyi.
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A new eudesmane sesquiterpenoid, artemisargin A (1), two new guaianolide sesquiterpenoids, artemisargins B (2) and C (3), along with three known sesquiterpenoids (4-6), were isolated from the leaves of Artemisia argyi. Their structures were determined by
Highly oxidized sesquiterpenes from Artemisia austro-yunnanensis.
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Eight new sesquiterpenes, including four guaianolides (1-4), one guaian sesquiterpene (5), one norguaianolide (6), one 1, 10-secoguaianolides (7), and one eudesmane sesquiterpene (8), along with fourteen known sesquiterpenes (9-22) were isolated from the whole plants of Artemisia austro-yunnanensis.
Yomogin inhibits the degranulation of mast cells and the production of the nitric oxide in activated RAW 264.7 cells.
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Yomogin (1), an eudesmane sesquiterpene isolated from Artemisia princeps, was tested for the effects on the degranulation process of cultured mast cells and on the nitric oxide production in LPS-activated murine macrophages. It demonstrated a significant inhibition on the release of
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