Healthy

Brain Scan-PET

Brain Scan-MRI

Arterial Line

Venous Line

Blood Sampling

National Institutes of Health Clinical Center, 9000 Rockville Pike

Imaging of CB1 Receptors Using (11C)SD5024

PET Imaging of CB1 Receptors Using [11C]SD5024

National Institute of Mental Health (NIMH)

Preoperative Gabapentin Elixir (1200 mg) AND Postoperative Placebo Elixir (300 mg x 6 doses)

Preoperative Gabapentin Elixir (1200 mg) AND Postoperative Gabapentin Elixir (300 mg x 6 doses)

Preoperative Placebo Liquid (1200 mg) AND Postoperative Placebo Elixir (300 mg x 6 doses)

Preoperative Gabapentin Elixir (1200 mg) AND Postoperative Placebo Elixir (300 mg x 6 doses)
Gabapentin: Gabapentin 1200 mg (24 cc) by mouth 1 hour prior to surgery AND Placebo 300 mg (6cc) by mouth x 6 doses after surgery (0800PM the evening of surgery, 0800AM postoperative day 1, 0200PM postoperative day 1, 0800PM postoperative day 1, 0800AM postoperative day 2, 1200PM postoperative day 2)

1 Preoperative Gabapentin Liquid

Preoperative Gabapentin Elixir (1200 mg) AND Postoperative Gabapentin Elixir (300 mg x 6 doses)
Gabapentin: Gabapentin 1200 mg (24 cc) by mouth 1 hour prior to surgery AND Gabapentin 300 mg (6cc) by mouth x 6 doses after surgery (0800PM the evening of surgery, 0800AM postoperative day 1, 0200PM postoperative day 1, 0800PM postoperative day 1, 0800AM postoperative day 2, 1200PM postoperative day 2)

2 Preoperative and Postoperative Gabapentin Liquid

Preoperative Placebo Liquid (1200 mg) AND Postoperative Placebo Elixir (300 mg x 6 doses)
Placebo: Placebo 1200 mg (24 cc) by mouth 1 hour prior to surgery AND Placebo 300 mg (6cc) by mouth x 6 doses after surgery (0800PM the evening of surgery, 0800AM postoperative day 1, 0200PM postoperative day 1, 0800PM postoperative day 1, 0800AM postoperative day 2, 1200PM postoperative day 2)

3 Preoperative and Postoperative Placebo Liquid

Total

Sex: Female, Male

Region of Enrollment

The amount of intraoperative and postoperative opioids used will be collected and analyzed for the three different arms.

Evaluate the Amount of Diluadid Given Postoperatively

Number of Participants Who Experience Incidence of Postoperative Nausea.

Evaluate Incidence of Respiratory Depression as Evidenced by Pulse Oximetry Data

Overall Study

Larry Field

Obesity, Morbid

Postoperative Pain

Postoperative Nausea and Vomiting

Gabapentin 1200 mg (24 cc) by mouth 1 hour prior to surgery AND Gabapentin 300 mg (6cc) by mouth x 6 doses after surgery (0800PM the evening of surgery, 0800AM postoperative day 1, 0200PM postoperative day 1, 0800PM postoperative day 1, 0800AM postoperative day 2, 1200PM postoperative day 2)

Gabapentin

Placebo 1200 mg (24 cc) by mouth 1 hour prior to surgery AND Placebo 300 mg (6cc) by mouth x 6 doses after surgery (0800PM the evening of surgery, 0800AM postoperative day 1, 0200PM postoperative day 1, 0800PM postoperative day 1, 0800AM postoperative day 2, 1200PM postoperative day 2)

Placebo

Gabapentin 1200 mg (24 cc) by mouth 1 hour prior to surgery AND Placebo 300 mg (6cc) by mouth x 6 doses after surgery (0800PM the evening of surgery, 0800AM postoperative day 1, 0200PM postoperative day 1, 0800PM postoperative day 1, 0800AM postoperative day 2, 1200PM postoperative day 2)

Medical University of South Carolina

Study of the Effect of the Drug Gabapentin on Postoperative Pain and Incidence of Postoperative Nausea and Vomiting

The Effect of Gabapentin on Acute Pain and PONV in Bariatric Surgical Patients

1. Inactive Placebo Pill

2. Active Medication

Change in food intake from baseline to week 3.

gamma aminobutyric acid/adipositas

Imaging of CB1 Receptors Using (11C)SD5024

Study of the Effect of the Drug Gabapentin on Postoperative Pain and Incidence of Postoperative Nausea and Vomiting

Effects of Divalproex Sodium on Food Intake, Energy Expenditure, and Posture Allocation

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