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Seite 1 von 90 Ergebnisse
[Protective effect of the histone deacetylase inhibitor ACY1215 against brain edema in mice with acute liver failure].
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Objective: To investigate the protective effect of ACY1215 (Rocilinostat), a histone deacetylase inhibitor, against brain edema in mice with acute liver failure. Methods: Lipopolysaccharide combined with D-galactosamine was used to establish a mouse model of acute liver failure, and ACY1215 was used
Abrogated Caveolin-1 expression via histone modification enzyme Setdb2 regulates brain edema in a mouse model of influenza-associated encephalopathy.
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Influenza-associated encephalopathy (IAE) is a serious complication that can follow influenza virus infection. Once a cytokine storm is induced during influenza virus infection, tight junction protein disruption occurs, which consequently leads to blood-brain barrier (BBB) breakdown. However, the
Anti-rheumatic activity of Phenethyl isothiocyanate via inhibition of histone deacetylase-1.
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Rheumatoid Arthritis (RA) affects approximately 1% of the total world population. Despite incessant research and development of new therapeutic agents, management of RA is still a troublesome affair. Histone Deacetylase 1 (HDAC1) is an epigenetic regulator which play important role in pathogenesis
N-acetyl-heparin attenuates acute lung injury caused by acid aspiration mainly by antagonizing histones in mice.
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Acute lung injury (ALI) is the leading cause of death in intensive care units. Extracellular histones have recently been recognized to be pivotal inflammatory mediators. Heparin and its derivatives can bind histones through electrostatic interaction. The purpose of this study was to investigate 1)
Role of histone modification and DNA methylation in signaling pathways involved in diabetic retinopathy.
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Retinopathy, characterized by an alteration of the retinal microvasculature, is a common complication of diabetes mellitus. These changes can cause increased permeability and alter endothelial cell proliferation, edema, and abnormal neovascularization and eventually result in blindness. The
Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice.
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BACKGROUND
Histone deacetylase (HDAC) inhibitors, developed as promising anti-tumor drugs, exhibit their anti-inflammatory properties due to their effects on reduction of inflammatory cytokines.
OBJECTIVE
To investigate the protective effect of butyrate, a HDAC inhibitor, on lipopolysaccharide
[Inhibitory effect of a novel histone deacetylases inhibitor FK228 on human colon cancer HCT-116 cells in vitro and in vivo].
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OBJECTIVE
To investigate the inhibitory effects of a novel histone deacetylases inhibitor FK228 on human colon cancer HCT-116 cells in vitro and in vivo, and evaluate its toxicity and side effects.
METHODS
The in vitro growth inhibitions of HCT-116 cells by different concentrations of FK228 and 5-Fu
Saponins isolated from roots of Chlorophytum borivilianum reduce acute and chronic inflammation and histone deacetylase.
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OBJECTIVE
The roots of Chlorophytum borivilanum are used in traditional medicine for the treatment of arthritis and inflammation. The aim of the work was to evaluate the anti-inflammatory activity of isolated saponins from Chlorophytum borivilianum (ISCB).
METHODS
The ISCB was screened using the
Histone Deacetylase Inhibition Restores Retinal Pigment Epithelium Function in Hyperglycemia.
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In diabetic individuals, macular edema is a major cause of vision loss. This condition is refractory to insulin therapy and has been attributed to metabolic memory. The retinal pigment epithelium (RPE) is central to maintaining fluid balance in the retina, and this function is compromised by the
Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability and endothelial glycocalyx disruption following fluid-percussion brain injury in the rat.
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BACKGROUND
Traumatic brain injury causes a disruption of the vascular endothelial glycocalyx layer that is associated with an overactivation of the sympathoadrenal system. We hypothesized that early and unselective beta-blockade with propranolol alone or in combination with the alfa2-agonist
Imaging Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3 K27M Mutation.
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The 2016 World Health Organization Classification of Tumors of the Central Nervous System includes "diffuse midline glioma with histone H3 K27M mutation" as a new diagnostic entity. We describe the MR imaging characteristics of this new tumor entity in pediatric patients.
We retrospectively reviewed
[Effect of heparin on histone-mediated the expression of von Willebrand factor and fibrinogen in lung tissue].
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Kabuki syndrome as a cause of non-immune fetal hydrops/ascites.
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Kabuki syndrome (MIM 147920) is a well-described, multiple congenital anomaly syndrome characterized by growth and developmental delay, cardiac, renal, and vertebral anomalies, as well as persistent fetal finger pads and distinct facial features. Facies are characterized by long palpebral fissures
Human CRP defends against the toxicity of circulating histones.
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C-reactive protein (CRP) is an acute-phase protein that plays an important defensive role in innate immunity against bacterial infection, but it is also upregulated in many noninfectious diseases. The generic function of this highly conserved molecule in diseases that range from infection,
Unfractionated heparin inhibits histone-mediated coagulation activation and thrombosis in mice
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Introduction: Histones play pivotal roles in the pathophysiology of sepsis. Different studies have reported that unfractionated heparin (UFH) can improve histone-mediated organ dysfunction. However, in such studies, UFH was usually
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