There is provided a composition for preventing and treating obesity including high water-soluble .beta.-cyclodextrin derivatives as an effective component. Specifically, the composition including the high water-soluble .beta.-cyclodextrin derivatives, especially, 2-hydroxypropyl-.beta.-cyclodextrin (HP-.beta.-CD, HPBCD) has effects on suppressing an increase in body weight induced by a high fat diet, suppressing appetite through decreasing an amount of dietary intake, decreasing body fat, decreasing liver weight, and significantly decreasing a sharp increase of blood sugar induced by intaking glucose and maltose on an empty stomach so that it can be useful for preventing and treating obesity, preventing and treating various diseases induced by obesity, and suppressing a sharp increase of blood sugar after dinner.

Han; Gyoon-Hee

Choi; Yong Seok

Han; Sang-Bae

Lee; Jong-Ho

Kim; Hwan-Mook

Park; Song-Kyu

Lee; Ki-Ho

Kang; Jong-Soon

Lee; Ki-Hoon

Lee; Chang-Woo

Song Ho Biomed Co., Ltd.

Composition for treating and preventing obesity including high water-soluble 2-hydroxypropyl-betacyclodextrin as effective component

The invention relates to a combination of heat-treated nutritional composition having a carbohydrate fraction comprising a) 5-30 wt % of one or more monosaccharides selected from galactose, ribose and mannose; b) carbohydrates capable of providing b1) sustained release glucose and b2) rapidly available glucose; c) optionally fructose; d) glucose-containing disaccharides other than maltose and sucrose; and e) optionally sugar polyols. The invention also pertains to the use of such a heat-treated nutritional composition for controlling glucose levels in blood and/or tissue, especially for preventing and/or treating diabetics, insulin-resistance, obesity, postprandial glucose response, metabolic syndrome, syndrome X, hyperglycemia, hypertriglyceridemia, hyperinsulinemia, dyslipidemia, dysfibrinolysis and/or disorders associated with major surgery or trauma.

maltose/adipositas

Composition for treating and preventing obesity including high water-soluble 2-hydroxypropyl-betacyclodextrin as effective component

Carbohydrate fraction and use thereof for a flat postprandial glucose response

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