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meningitis/carbohydrate
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Brain carbohydrate metabolism during experimental Haemophilus influenzae meningitis.
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Five-day-old infant rats which acquire Haemophilus influenzae b bacteremia and meningitis after intranasal inoculation have a transient depression in weight gain (2 days), but then continue to grow at the same rate as strain U--11 inoculated controls. Brain lactate, glucose, and glycogen
[A case of severe cranial injury complicated by pneumoencephalos, subarachnoid hemorrhage, meningitis, rhinoliquorrhea, diabetes insipidus and carbohydrate metabolism disorder].
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Clinical and microbiological features of cryptococcal meningitis.
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BACKGROUND
In this study, the clinical features, underlying diseases and clinical outcomes of patients with cryptococcosis were investigated. In addition, a molecular analysis of the Cryptococcus neoformans species complex isolated from these patients was performed.
METHODS
A prospective study of 62
Experimental validation of the predicted binding site of Escherichia coli K1 outer membrane protein A to human brain microvascular endothelial cells: identification of critical mutations that prevent E. coli meningitis.
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Escherichia coli K1, the most common cause of meningitis in neonates, has been shown to interact with GlcNAc1-4GlcNAc epitopes of Ecgp96 on human brain microvascular endothelial cells (HBMECs) via OmpA (outer membrane protein A). However, the precise domains of extracellular loops of OmpA
Purification of a galactosyl-alpha 1-4-galactose-binding adhesin from the gram-positive meningitis-associated bacterium Streptococcus suis.
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Streptococcus suis causes meningitis, sepsis, and other serious infections in newborn and young pigs and in adult humans. The Gal alpha 1-4Gal-binding adhesin of S. suis was purified to homogeneity by ultrasonic treatment, fractional ammonium sulfate precipitation, and preparative polyacrylamide gel
Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model.
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LMB-7 [B3(Fv)-PE38] is a single-chain immunotoxin constructed from the murine monoclonal antibody B3 and a truncated from of Pseudomonas exotoxin PE38. Antibody B3 recognizes a carbohydrate epitope found on solid tumors that frequently invade the intrathecal space and cause neoplastic meningitis. We
Diagnosis of bacterial meningitis by gas-liquid chromatography. I. Chemotyping studies of Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, and Escherichia coli.
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With the use of gas-liquid chromatographic techniques, the chemical characteristics of Streptococcus pneumoniae type 3, Escherichia coli, group B Neisseria meningitidis, Haemophilus influenzae type b, and Staphylococcus aureus, organisms that commonly cause bacterial meningitis, were identified. The
Antiinflammatory effects in experimental meningitis of prokaryotic peptides that mimic selectins.
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The lectin domains of two subunits of pertussis toxin, S2 and S3, share amino acid sequence similarity with the lectin domains of the eukaryotic selectin family. During inflammation, selectins appear on endothelial cells and promote recruitment of leukocytes by reversibly binding carbohydrates.
Meningitis due to Prototheca wickerhamii: rare case in China.
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A rare case of Prototheca wickerhamii meningitis is reported in a patient without any underlying immunodeficient condition. Wet-mount microscopy and culture of cerebral spinal fluid specimens, along with temperature resistance, cycloheximide tolerance, carbohydrates assimilation, including API 20C
Rapid and reliable techniques for the laboratory detection of bacterial meningitis.
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Microorganisms encountered in cerebrospinal fluid require rapid and accurate means of detection and identification in the laboratory. Although restricted to morphologic study and Gram reaction, the Gram stain of cerebrospinal fluid has been the primary diagnostic tool for preliminary diagnosis of
Efficacy of compartmental administration of immunotoxin LMB-1 (B3-LysPE38) in a rat model of carcinomatous meningitis.
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LMB-1 (B3-LysPE38) is an immunotoxin composed of the tumor-reactive monoclonal antibody B3 and a genetically engineered form of Pseudomonas exotoxin. Monoclonal antibody B3 reacts with a carbohydrate epitope that is found on a number of solid tumors (e.g., breast, ovarian, and lung carcinomas) that
Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases.
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The major human pathogen Streptococcus pneumoniae plays a key role in several disease states including septicaemia, meningitis and community-acquired pneumonia. Although vaccines against S. pneumoniae are available as prophylactics, there remains a need to identify and characterise novel chemical
Bacterial Adhesion of Streptococcus suis to Host Cells and Its Inhibition by Carbohydrate Ligands.
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Streptococcus suis is a Gram-positive bacterium, which causes sepsis and meningitis in pigs and humans. This review examines the role of known S. suis virulence factors in adhesion and S. suis carbohydrate-based adhesion mechanisms, as well as the inhibition of S. suis adhesion by anti-adhesion
Organic chemistry and immunochemical strategies in the design of potent carbohydrate-based vaccines.
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A brief overview of carbohydrate antigens processing and uptakes involved in the adaptive immune system is highlighted. To counter balance the poor immunogenicity and T-cell independent characteristics of carbohydrate antigens, chemists have developed original hybrid molecules aimed at targeting
Biochemical differentiation of Haemophilus influenzae. Additional characterization of biotypes by carbohydrate fermentation patterns.
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A total of 295 strains of H. influenzae was characterized by serotyping and biochemotyping following the scheme of Kilian. Biotype II was the biotype most frequently seen (41.4% of the strains). The strong correlation of serotype b with biotype I was confirmed. Carbohydrate degradation was evaluated
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