Subjects who are SARS-CoV-2 PCR+ve and/or have diagnostic CXR or CT chest features of COVID -19

subjects admitted with COVID-19 like symptoms but are SARS-CoV-2 PCR-ve and have CXR or CT chest that show low probability of COVID-19 will form the control group

blood and urine samples for vascular phenotpying marker, immuno phenotyping markers and future biomarker studies

COVID

Hypertension

24 hour ambulatory blood pressure monitoring

ABPM

Rarefaction

NHS Greater Glasgow and Clyde

COVID-19 Blood Pressure Endothelium Interaction Study (OBELIX)

COVID-19 Blood Pressure Endothelium Interaction Study

Ambulatory Blood Pressure Monitoring systolic blood pressure

Ambulatory Blood Pressure Monitoring diastolic blood pressure

Day Ambulatory Blood Pressure Monitoring systolic blood pressure

Day Ambulatory Blood Pressure Monitoring diastolic blood pressure

Night Ambulatory Blood Pressure Monitoring systolic blood pressure

Night Ambulatory Blood Pressure Monitoring diastolic blood pressure

The fall in pressure, called the "dip", is defined as the difference between daytime mean systolic pressure and nighttime mean systolic pressure expressed as a percentage of the day value

he morning surge was defined as the difference between the mean systolic blood pressure during the 2 hours after waking and arising minus the mean systolic blood pressure during the hour that included the lowest blood pressure during sleep.

24 hour Ambulatory Blood Pressure Monitoring heart rate

Day Ambulatory Blood Pressure Monitoring heart rate

Night Ambulatory Blood Pressure Monitoring heart rate

University of Glasgow

Sample of patients died with Covid-19 disease and pulmonary disease

Sample of patients died with Covid-19 disease and pulmonary disease with clear cardiovascular involvement

Sample of patient died with different types of myocarditis without Covid-19 disease. These samples are used as control and are part of database of previously collected samples of CVPath Institute Inc.

COVID-19

ASST Ospedale Papa Giovanni XXIII

Cardiac Injury in COVID-19: a Pathology Study

Pathology and Pathogenesis of Cardiac Injury in COVID-19 Infections in Humans

Describe the cardiac pathological findings from series of 50 patients dying from COVID-19 using cardiac samples sent to CVPath Institution from Papa Giovanni XXIII Hospital, Bergamo to study the correlations between clinical risk factors and myocardial findings and difference from other viral myocarditis

Understand the relationship between viral load in cardiac tissues and the extent of damage seen on myocardial histological sections

Co-localize the SARS-CoV-2 using RNAscope in situ hybridization, with its entry receptor ACE2 and serine protease TMPRSS2 in different cell types found in the heart, such as endothelial, smooth muscle, myocardial, fibroblastic and inflammatory cells to better understand the pathogenesis of the disease.

GGuagliumi

MD Cardiologist

A.O. Ospedale Papa Giovanni XXIII

CVPath Institute Inc. Renu Virmani, Aloke Finn

A.O. Ospedale Papa Giovanni XXIII, Anatomia Patologica, Dr Andrea Gianatti, co-PI

USPIO given 2-4 days post MI Ferumoxytol enhanced MRI

USPIO given 5-7 days post MI Ferumoxytol enhanced MRI

USPIO given 11-21 days post MI Ferumoxytol enhanced MRI

Myocardial Infarction

Inflammation

Ferumoxytol enhanced MRI

Royal Infirmary of Edinburgh

Clinical Research Imaging Centre

IRon Nanoparticle Enhanced MRI in the Assessment of Myocardial infarctioN

ASSESSMENT OF CELLULAR INFLAMMATION FOLLOWING ACUTE MYOCARDIAL INFARCTION Application Of Ultrasmall Superparamagnetic Particles Of Iron Oxide

Marker of USPIO uptake (and inflammation) in each cohort after myocardial infarction.
The USPIO infusion is given at different time-points for each cohort. However only the R2* value on the MRI 24 hours after infusion will constitute the primary end-point

myocarditis/protease

COVID-19 Blood Pressure Endothelium Interaction Study (OBELIX)

Cardiac Injury in COVID-19: a Pathology Study

IRon Nanoparticle Enhanced MRI in the Assessment of Myocardial infarctioN

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