The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPAR.gamma.2, LPL and .alpha.P2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues.

New York University

The General Hospital Corporation

Compositions and methods for treating obesity, obesity related disorders and for inhibiting the infectivity of human immunodeficiency virus

Lee-Huang; Sylvia

Huang; Paul L.

Huang; Philip Lin

Zhang; Dawei

Zhang; John Z. H.

Chang; Young Tae

Lee; Jae Wook

Bao; Ju

Sun; Yongtao

A method to suppress obesity, comprising administering to a subject in need thereof an effective amount of a composition comprising the following components (A) and (B): (A) oleuropein; and (B) a sulforaphane compound, wherein the amount of component (A) alone contained in the composition does not result in a fat accumulation-suppressing effect, and the amount of component (B) alone contained in the composition does not result in a fat accumulation-suppressing effect.

oleuropein/adipositas

Compositions and methods for treating obesity, obesity related disorders and for inhibiting the infectivity of human immunodeficiency virus

Compositions and methods for treating obesity, obesity related disorders and for inhibiting the infectivity of human immunodeficiency virus

Anti-obesity composition

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