Whole exome, genome wide and RNA sequencing

Multiple Myeloma

Monoclonal Gammopathy of Undetermined Significance

The aspirate sample obtained for research at the time a standard-of-care biopsy is taking place will be approximately 40cc. Bone marrow aspiration removes bone marrow fluid and cells through a needle placed into the bone. Usually this sample is taken from the back of the pelvic bone, but it may also be taken from the sternum or the front of the pelvic bone. A bone marrow biopsy removes bone with the marrow inside and is done prior to the aspirate. Each biopsy and aspirate procedure takes approximately 15 minutes total. Bone marrow aspirate may be collected in a separate tube for research or collected from the standard-of-care specimen with left-over aspirate not otherwise needed for clinical purposes, or from previous procedures.

Bone Marrow Aspirate and Biopsy

University of Iowa

Sleep Apnea in Patients With MGUS and MM

Melissa Bates

Assistant Professor

Department of Health and Human Services

If patients are qualified for the study and elect to submit a sample for DNA it will be collected and stored at the Indiana biobank

Indiana University Simon Cancer Center

Observation of the Incidence and Natural History of MGUS in Patients Undergoing Weight Reduction Surgery

Prospective Observation of the Incidence and Natural History of Monoclonal Gammopathy in Patients Undergoing Weight Reduction Surgery

The primary analysis focuses on the estimation of the rate of MGUS for this specific population.

Individual patient data will not be shared

Indiana University

Eligible patients will be started on Liraglutide up to 1.8 mg sc once daily, as adjunct weight loss treatment for 12 months.

Monoclonal Gammopathies

Overweight

Obesity

Interventional, single-group, open label pilot study. The investigators will identify monoclonal gammopathy patients whose antibodies are lipid/VAT targeted (goal is 10 initially as a pilot) and who are overweight/obese (BMI > 27). Eligible patients will be started on Liraglutide up to 1.8 mg sc once daily, as adjunct weight loss treatment for 12 months.

Liraglutide

Antigen-Lipid-Driven Monoclonal Gammopathies Targeting Epicardial Fat

Reduction of Antigen-Lipid-Driven Monoclonal Gammopathies by Targeting Epicardial Fat and Its Lipids Content With Liraglutide: A Glucagon Like Peptide-1 Receptor Analogue (GLP-1RA)

paraproteinemias/adipositas

Sleep Apnea in Patients With MGUS and MM

Observation of the Incidence and Natural History of MGUS in Patients Undergoing Weight Reduction Surgery

Antigen-Lipid-Driven Monoclonal Gammopathies Targeting Epicardial Fat

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