Study subjects that present MACE at the 36 months follow-up

Study subjects that do not present MACE at the 36 months follow-up

Venous blood sample collection during the acute coronary event for evaluation of serum levels of hsCRP, IL-6, matrixmetalloproteases MMP9, Adhesion molecules (VCAM, ICAM), alfa tumour necrosis factor, hs-cTnI, NTproBNP

Coronary Stenosis

Acute Coronary Syndrome

Acute Myocardial Infarction

Atheromatous Plaques

Atheroscleroses, Coronary

Non-ST Elevation Myocardial Infarction (nSTEMI)

2D transthoracic echocardiography
128-multislice CT coronary angiography with the evaluation of: epicardial fat volume, plaque burden, total and local calcium score, markers for lesion severity; morphological plaque characteristics; plaque components evaluated via volumetric and planimetric units; markers of plaque vulnerability (necrotic core, low attenuation plaque, spotty calcification, napkin ring sign, positive remodeling).
Shear stress evaluation via computational fluid dynamics.
Intracoronary imaging techniques: IVUS and OCT.

Cardiac imaging tests

Venous blood sample collection

Cardio Med

Systemic, Pancoronary and Local Coronary Vulnerability

Systemic, Pancoronary and Local Plaque Vulnerability for Image-based Prediction of Acute Coronary Syndromes - the VIP Study

Acute coronary syndromes (unstable angina, ST and non-ST elevation myocardial infarction), emergency revascularization of non-culprit lesions, repeated hospitalizations for cardiovascular reasons, acute cerebrovascular event.

Reevaluation of the non-culprit lesions via 128-multislice CT coronary angiography with analysis of the degree of stenosis caused by the non-culprit lesion.

Reevaluation of the non-culprit lesions via 128-multislice CT coronary angiography with analysis of the number of CT markers for coronary plaque vulnerability (low attenuation plaque, spotty calcification, napkin ring sign, positive remodeling).

All IPD that underlie results in a publication will be available for interested parties.

pericardial effusion/− nicotin

Systemic, Pancoronary and Local Coronary Vulnerability

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