Breast Cancer

Bone Metastasis

Pain

chemoradiation

Rabin Medical Center, Beilinson Campus

Chemoradiation for Bone Metastasis

Chemoradiation With Capecitabine for Palliation of Pain From Bone Metastasis

Patients were asked to score their pain on a scale of 0 (no pain) to 10 (worst possible pain) before treatment and at 1, 2, 4, 8 and 12 weeks after treatment initiation.

Consumption of analgesics was evaluated by the physician using the 5-point WHO score, as follows: level 0, no analgesics required; level 1, non-narcotic analgesics required occasionally; level 2, non-narcotic analgesics required regularly; level 3, narcotic analgesics required occasionally; level 4, narcotic analgesics required regularly

Rabin Medical Center

Sheba Medical Center

General anaesthesia using 70% Nitrous Oxide with fraction of inspired oxygen at 30%

General anaesthesia not containing Nitrous oxide with fraction of inspired oxygen at 30%

Nitrous Oxide as an inspired concentration of 70% in 30% Oxygen

N2O Group (FiO2 0.3)

Nitrous Oxide free air and inspired Oxygen concentration of 30%

N2O Free Group (FiO2 0.3)

Total

Sex: Female, Male

Race/Ethnicity, Customized

N2O Group (FiO2 0.3)
Nitrous Oxide: 70% N2O V's No N2O
Nitrous Oxide: N2O 70% v's No N2O

Nitrous Oxide: 70% N2O (FiO2 0.3)

N2O free group (FiO2 0.3)
Nitrous Oxide: 70% N2O V's No N2O
Nitrous Oxide: N2O 70% v's No N2O

The Primary Endpoint is a Composite of Death and Cardiovascular Events (Clinical and Silent MI, Cardiac Failure, Cardiac Arrest, Pulmonary Embolism, and Stroke) Measured at 30 Days After Surgery.

Myocardial Infarction (MI)

Cardiac Arrest

Pulmonary Embolism

Stroke

Wound Infection

Hospital Stay (Days)

General anaesthesia containing Nitrous oxide and fraction of inspired oxygen of 30%

Nitrous Oxide Group

General anaesthesia not containing Nitrous oxide with fraction of inspired oxygen of 30%

No Nitrous Oxide

Overall Study

Professor Paul Myles

N2O Group (FiO2 0.3)
Nitrous Oxide: 70% N2O V's No N2O
General anaesthesia containing Nitrous oxide and fraction of inspired oxygen of 30%

Nitrous Oxide: 70% N2O

Nitrous Oxide free group (FiO2 0.3)
Nitrous Oxide: N2O 70% v's No N2O
General anaesthesia not containing Nitrous oxide and fraction of inspired oxygen of 30%

Nitrous Oxide Free

Coronary Artery Disease

General anaesthesia with the inclusion of Nitrous Oxide at 70%

Nitrous Oxide

General anaesthesia with no use of Nitrous Oxide

Alfred Hosptial

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

Large, Randomised, Parallel-group, Controlled Trial, With Patients Randomly Allocated to Either N2O-containing (70% N2O in Oxygen [FiO2 0.3]) or N2O-free (70% Nitrogen in Oxygen [FiO2 0.3]).

Bayside Health

National Health and Medical Research Council, Australia

international, randomised, assessor-blinded trial in patients aged at least 45 years with known or suspected coronary artery disease having major non-cardiac surgery.

The treating anaesthetist will be unblinded to the allocation. All other personnel (surgeon, participant and outcome assessor are all blinded to treatment.

thymidine/infarzierung

Chemoradiation for Bone Metastasis

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

Capecitabine and Oxaliplatin in Treating Patients With Metastatic Breast Cancer

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