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15 Ergebnisse
Ultrasound-induced epileptiform activity in rats treated with hexachlorobenzene.
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Hexachlorobenzene (HCB), an environmental contaminant, has caused spontaneous convulsions in infants and neonate rats born and breast-fed from exposed mothers as well as in weanling rats exposed for many weeks. This study aimed to determine if HCB causes epileptiform convulsions in adult rats. For
Modulation of p,p'-DDT-induced tremor by catecholaminergic agents.
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p,p'-DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane; 75 mg/kg) or corn oil was administered po to male Fischer 344N rats. Tremor was quantified 8 hr later by spectral analysis of whole body movements. The effect of sc injection of pharmacological challenges on the spectral profile of body
The effect of neonatal exposure to diethylstilbestrol, genistein, and zearalenone on pituitary responsiveness and sexually dimorphic nucleus volume in the castrated adult rat.
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The neonatal hormone environment determines the sexually differentiated pattern of brain growth. Estrogens, derived from intracerebral aromatization of testosterone, promote male sexual central nervous system (CNS) development. Developing animals may also encounter estrogens from plant, fungal, and
Hematopoietic activity of Smilax aristolochiaefolia (zarzaparrilla) in mice with aplastic anemia.
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Smilax aristolochiaefolia (Liliaceae) has been used in Mexican traditional medicine for the treatment of tumors, leprosy, anemia and as a tonic for skin infections and anemia. Aplastic anemia (AA) was induced in CD1 mice 8-12 weeks old distributed 10 animals each in Groups VSC, AA, AASa and AAr.
Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus.
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BACKGROUND
This paper is based on ethnobotanical interviews conducted from 1996-2000 in Trinidad and Tobago with thirty male and female respondents.
METHODS
A non-experimental validation was conducted on the plants used for urinary problems and diabetes mellitus: This is a preliminary step to
Hepatoprotective effect of the aqueous extract of Simarouba amara Aublet (Simaroubaceae) stem bark against carbon tetrachloride (CCl4)-induced hepatic damage in rats.
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Simarouba amara stem bark decoction has been traditionally used in Brazil to treat malaria, inflammation, fever, abdominal pain, diarrhea, wounds and as a tonic. In this study, we investigate the hepatoprotective effects of the aqueous extract of S. amara stem bark (SAAE) on CCl4-induced hepatic
Differential effects of the endocrine-disrupting compounds bisphenol-A and octylphenol on gonadotropin secretion, in prepubertal ewe lambs.
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This study examined the effects of long-term exposure to the endocrine-disrupting compounds (EDCs) Bisphenol-A (BPA) and Octylphenol (OP) on gonadotrophin secretion in pre-pubertal female sheep. Four-week-old, female lambs were randomly allocated to four groups (n=6), and twice each week treated
Acute and subacute effects of naturally occurring estrogens on luteinizing hormone secretion in the ovariectomized rat: Part 2.
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Acute intravenous administration of the phytoestrogen genistein (G) blocks the gonadotropin-releasing hormone-(GnRH)-induced rise of luteinizing hormone (LH) in ovariectomized rats. The present experiments were performed to determine whether subacute administration of G or the mycoestrogens
Inversion of gravitropism by symmetric blue light on the clinostat.
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Gravitropic stimulation of maize (Zea mays L.) seedlings resulted in a continuous curvature of the coleoptiles in a direction opposing the vector of gravity when the seedlings were rotated on a horizontal clinostat. The orientation of this response, however, was reversed when the gravitropic
Lack of effects of indomethacin on estradiol feedback control of luteinizing hormone in ovariectomized ewes.
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We tested the hypothesis that indomethacin, a potent inhibitor of prostaglandin synthesis, would modify estradiol's effects on tonic and surge concentrations of LH in chronically ovariectomized ewes during the anestrous season. Ewes (n = 21) were assigned randomly to one of four treatments:
Histology and ultrastructure of the adult mouse ovary following a single prenatal exposure to diethylstilbestrol.
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Histology, selective histochemistry and electron microscopy were used to examine the ovarian structure of offspring from mice administered DES (10 micrograms/kg in 0.1 cc of corn oil, subcutaneously) or corn oil alone on Day 15 of gestation. Offspring were sacrificed at 7 months of age. Ovarian
Behavioural effects of tetrachloroethylene exposure in rats: acute and subchronic studies.
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This study was carried out to compare the neurobehavioural profile of acute and subchronic tetrachloroethylene (perchloroethylene, PCE) exposure in rats. In the acute study, a single bolus of 50 and 500 mg/kg of PCE in corn oil was administered by gavage. In the subchronic experiments, rats were
Sublethal effects of subacute exposure to RDX (1,3,5-trinitro-1,3,5-triazine) in the northern bobwhite (Colinus virginianus).
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Northern bobwhite (Colinus virginianus) were orally exposed via gavage to 0, 0.5, 3, 8, 12, or 17 mg/kg of RDX (1,3,5-trinitro-1,3,5-triazine) in corn oil daily for 14 d to evaluate sublethal effects of this explosive in birds. Mortality occurred at a rates of 100, 67, and 25% for the 17, 12, and 8
Possible role of vasopressin in the thermoregulatory response to chlorpyrifos in the rat.
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Arginine vasopressin is a naturally occurring antipyretic which is released into the CNS to prevent excessive elevations in body temperature during fever. Circulating levels of arginine vasopressin may also have a role in the tonic control of body temperature. We have found that the organophosphate
Subacute toxicity of oral 2,6-dinitrotoluene and 1,3,5-trinitro-1,3,5-triazine (RDX) exposure to the northern bobwhite (Colinus virginianus).
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Military activities associated with training have resulted in soil residues of munition compounds and their breakdown products. Often, these areas are valuable habitats used by birds. To evaluate the possibility of adverse effects in birds, the effects from oral exposures of 2,6-dinitrotoluene
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