Regulation of reactive oxygen species production by peripheral blood neutrophils from women with postpartum endometritis.

Production of reactive oxygen species in unfractionated peripheral blood increased in parturient women without postpartum infectious complications and patients with postpartum endometritis. The control group included nonpregnant women with normal reproductive function. Intergroup differences were revealed in the degree of respiratory burst activation with opsonized zymosan and response of isolated granulocytes to chemotactic peptide N-formyl-Met-Leu-Phen (1 muM). Production of reactive oxygen species tended to normal after therapy. We studied the effects of a specific mitogen-activated protein kinase p38MAPK inhibitor and inhibitors of tyrosine protein phosphatases and phosphatidylinositol-3-kinase. The role of p38MAPK in reactive oxygen species generation by cells changes significantly in parturient women.