The effect of hypothalamic peptides, neurohormone C and proline-rich peptide-1on the Ca ²⁺-handling system in heartin pathophysiological conditions

Atthe Institute of Biochemistry named after H. Buniatyan we discovered and studied hypothalamic peptides with coronary dilatory and antioxidant activities:neurohormone C (NC) and proline-rich peptide-1 (PRP-1). Both NC and PRP-1 exhibit cardioprotective effects, in part by restoring the calcium affinity for calcium-binding membrane proteins in cardiomyocytes. This affinity is diminished in the sarcoplasmic reticulum and mitochondriawith myocardial damage, heart failure, pancreatic necrosis and crush syndrome caused by isoproterenol. The peptides can also destroy the four detected toxic peptides and myocardial depressant factor, and protect against ischemia-reperfusion injury. Further studies of these peptides may be promising for the treatment of patients at high risk of cardiovascular disease, regardless of pathology.

Keywords: Biochemistry; Calcium-depot proteins; Cell biology; Crush syndrome; Heart; Hypothalamic peptides; Ischemia-reperfusion; Isoproterenol; Metabolite; Organ system; Pancreatitis; Pathophysiology.