Three new p-coumaroylated sesquiterpenoids from Pilea cavaleriei

Four p-coumaroylated sesquiterpenoids (1-4), including three new ones (1, 2, and 4), were isolated from the whole plants of Pilea cavaleriei. Their structures were established on the basis of comprehensive spectroscopic analysis and comparison with data reported in the literature. Compounds 1-4 were evaluated for their antimycobacterial activities, and 2 and 4 were active against Mycobacterium tuberculosis H₃₇Rv with the MIC values of 19.6 ± 0.19 and 17.4 ± 0.12 μg/mL, respectively.[Formula: see text].

Keywords: Pilea cavaleriei; Urticaceae; antimycobacterial activity; sesquiterpenoid.