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The effects of different fractions of Coriandrum sativum on pentylenetetrazole-induced seizures and brain tissues oxidative damage in rats.

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OBJECTIVE In the present work, the effects of different fractions of Coriandrum sativum (C. sativum), on pentylenetetrazole (PTZ)-induced seizures and brain tissues oxidative damage were investigated in rats. METHODS The rats were divided into the following groups: (1) vehicle, (2) PTZ (90 mg/kg),

Anticonvulsant Activity of Teucrium polium Against Seizure Induced by PTZ and MES in Mice.

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Teucrium polium (Labiatae) is a plant that widely grows in Iran. Some of species of Teucrium are used for a considerable range of actions in traditional medicine and T. polium has frequently been used as anticonvulsant. In this study, we investigated the protective effects of T. polium ethanolic

Impairment of avoidance behavior following short-term ingestion of ethanol, tertiary-butanol, or pentobarbital in mice.

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Acquisition of a shock avoidance task was impaired in mice after cessation of chronic consumption of ethanol, tertiary-butanol (t-butanol), or pentobarbital. The drugs were administered in liquid diets for 7 days after withdrawal of the drugs. The avoidance deficit was also observed 8 days after

Quantitative comparison of physical dependence on tertiary butanol and ethanol in mice: correlation with lipid solubility.

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Mice were made physically dependent on t-butanol and the withdrawal reaction was compared quantitatively with that produced by ethanol. The mice inhaled t-butanol vapor (50-140 mumol/1 of air) continuously for 1, 3, 6 or 9 days. Daily t-butanol blood levels were determined by gas chromatography,

Anticonvulsant Activity of Viola tricolor against Seizures Induced by Pentylenetetrazol and Maximal Electroshock in Mice.

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Background

Recently, there has been much more interest in the use of medicinal plants in search of novel therapies for human neurodegenerative diseases such as epilepsy. In the present study, we investigated the anticonvulsant effects of Viola tricolor (V. tricolor)

Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission.

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The study described here was carried out to investigate the anticonvulsant effect of different extracts of Centella asiatica with respect to cholinergic activity on pentylenetetrazol (PTZ)-induced seizures. Rats were randomly divided into eight groups of six rats each: nonepileptic rats treated with

[Synthesis of 1-N-aryloacetamidobutanol derivatives with anti-seizure effect].

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New derivatives of 1-N-aryloacetamidobutanols were obtained in the reaction of arylalkylcarboxylic acid chlorides with R, S, R(-), S(+) 1-amino-2-butanols. Structures of the obtained compounds have been confirmed by elemental analysis and IR-spectrometry. Results of pharmacological studies will be

Standardization of a traditional polyherbo-mineral formulation - Brahmi vati.

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The present study deals with standardization of an in-house standard preparation and three marketed samples of Brahmi vati, which is a traditional medicine known to be effective in mental disorders, convulsions, weak memory, high fever and hysteria. Preparation and standardization have been done by

Synthesis and anticonvulsant activity of 1,2-aminoalkanol derivatives.

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A series of 1,2-aminoalkanol derivatives were prepared and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scMet) assays and for neurotoxicity (TOX). Most interesting were the anticonvulsant results of

A new furofuran lignan with antioxidant and antiseizure activities from the leaves of Petasites japonicus.

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A new furofuran lignan (1) was isolated from the n-butanol fraction of the methanolic extract of the leaves of Petasites japonicus (Sieb. et Zucc.) Maxim. (Compositae). The structure of compound 1 was determined to be

The antiepileptic effect of Centella asiatica on the activities of Na/K, Mg and Ca-ATPases in rat brain during pentylenetetrazol-induced epilepsy.

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BACKGROUND To study the anticonvulsant effect of different extracts of Centella asiatica (CA) in male albino rats with reference to Na(+)/K(+), Mg(2+) and Ca(2+)-ATPase activities. METHODS Male Wistar rats (150+/-25 g b.w.) were divided into seven groups of six each i.e. (a) control rats treated

Role of saponins for the anticonvulsant effect of adventitious roots of Ficus religiosa.

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BACKGROUND The adventitious roots of Ficus religiosa L. (Moraceae) have been extensively used in traditional medicine for treatment of several disorders, including epilepsy. OBJECTIVE To investigate the possible anticonvulsant effect of the adventitious roots of Ficus religiosa, and to find the

Acute dependence on depressant drugs is determined by common genes in mice.

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Withdrawal seizure prone (WSP) and withdrawal seizure resistant (WRS) mice were genetically selected to express severe or mild handling-induced convulsions (HIC), respectively, after cessation of chronic ethanol (EtOH) vapor inhalation. The studies reported here tested WSP and WSR mice to determine

Pharmacological properties of some xanthone derivatives.

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A series of aminoalkanolic derivatives of xanthone were examined in some experimental models of epilepsia, i.e., pilocarpine, aminophylline and pentetrazole-induced seizures. A final objective of this research was to examine the action of these compounds on the central nervous system, namely on

Additive physical dependence: evidence for a common mechanism in alcohol dependence.

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In previous studies we demonstrated that mice could be made physically dependent with 3 or 6 days inhalation of t-butanol or ethanol vapor. In the present experiments the mice were treated with 3 days of t-butanol followed immediately by 3 days of ethanol at equipotent concentrations, for a total of

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