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bicuculline/οίδημα
Ο σύνδεσμος αποθηκεύεται στο πρόχειρο
Σελίδα 1 από 20 Αποτελέσματα
Pulmonary edema during bicuculline-induced seizures in rats.
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Σύνδεση εγγραφή
Bicuculline-induced epileptic brain injury. Transient and persistent cell changes in rat cerebral cortex in the early recovery period.
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Σύνδεση εγγραφή
It was earlier shown that bicuculline-induced status epilepticus gives rise to profound acute changes in the rat cerebral cortex, i.e. edema and neuronal alterations. In the present study, we explored to what extent interruption of the seizure activity reverses the changes observed. To that end,
Seizure-associated pulmonary edema and cerebral oxygenation in the rat.
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Σύνδεση εγγραφή
Cerebral partial pressure of O2 (PO2), relative changes in the ratio of reduced/oxidized cytochrome aa3, blood flow, and the arteriovenous difference in O2 content were measured during seizures with and without pulmonary edema. Seizures were induced with bicuculline (0.2-1.2 mg/kg iv) in rats
Role of pulmonary edema in phasic changes of cerebral oxygenation during serial seizures.
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Σύνδεση εγγραφή
To examine whether pulmonary dysfunction leads to episodes of cerebral hypoxia during recurrent seizures, measurements were made of arterial blood pressure, blood-gases, cerebral pO2, and relative changes in cytochrome a,a3 redox levels in anesthetized, paralyzed rats. Seizures were induced serially
Effects of chloride flux modulators in an in vitro model of brain edema formation.
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Brain edema is a serious consequence of hemispheric stroke and traumatic brain injury and contributes significantly to patient mortality. In the present study, we measured water contents in hippocampal slices as an in vitro model of edema formation. Excitotoxic conditions induced by
Pathogenesis of brain lesions caused by experimental epilepsy. Light- and electron-microscopic changes in the rat cerebral cortex following bicuculline-induced status epilepticus.
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Σύνδεση εγγραφή
Status epilepticus was induced in rats by the GABA receptor blocking agent, bicuculline, during artificial ventilation and with closely monitored physiologic parameters. After 1 or 2 h of status epilepticus the brains were fixed by perfusion with glutaraldehyde and processed for light and electron
Modulation of the gait deficit in arthritic rats by infusions of muscimol and bicuculline.
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Gait analysis in the adjuvant-induced arthritic rat model of chronic pain was used to examine the role of GABA(A) receptors in the development of pain. Drug solutions were administered continuously at 5+/-0.75 microl/h for 14 days via Alzet osmotic pumps (2ML2) placed under the skin of the back. The
[A pharmacological analysis of the role of GABA- and opioidergic systems in the development of brain edema].
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Σύνδεση εγγραφή
Opioid receptors blocker naloxone potentiated edematous effect of GABA-receptors blockers in experiments on rats. In combination with bicuculline and picrotoxine that agent leads to increased content of water in the brain and decreased brain tissue density. At the same time naloxone prevented
Specific gravity increases and brain water content decreases during short epileptiform seizures in discrete rabbit brain areas.
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Σύνδεση εγγραφή
In rabbits subjected to bicuculline (BC)- or pentylenetetrazole (PTZ)-seizures of 3 or 20 min duration or to adrenaline-induced hypertension, specific gravity (SG) was measured bilaterally in 15 regional brain areas in order to detect possible associations between the regionally limited blood-brain
Metabolic, circulatory, and structural alterations in the rat brain induced by sustained pentylenetetrazole seizures.
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Σύνδεση εγγραφή
Previous studies have demonstrated that bicuculline-induced seizures of 1-2 h in duration lead to structural, metabolic, and circulatory alterations in the rat brain. Such alterations were observed even though cerebral oxygenation seemed adequate. In the present study, we explored whether
Systemic and pulmonary vascular pressures during generalized seizures in sheep.
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Σύνδεση εγγραφή
The systemic vascular response to seizures is known but information on the hemodynamics of the pulmonary circulation is lacking, clouding an understanding of the pathophysiology of postical pulmonary edema. We investigated this problem using electrically induced single seizures and
Indomethacin and cerebrovascular permeability to albumin in acute hypertension and cerebral embolism in the rat.
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The experiments were performed to determine if indomethacin, a prostaglandin synthesis inhibitor, could reduce albumin extravasation and brain edema in some models of blood-brain barrier dysfunction. The blood pressure was increased by i.v. adrenaline or bicuculline in conscious rats with indwelling
GABA receptor ameliorates ventilator-induced lung injury in rats by improving alveolar fluid clearance.
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BACKGROUND
Mechanical ventilators are increasingly used in critical care units. However, they can cause lung injury, including pulmonary edema. Our previous studies indicated that γ-aminobutyric acid (GABA) receptors are involved in alveolar-fluid homeostasis. The present study investigated the role
Role of GABAergic antagonism in the neuroprotective effects of bilobalide.
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Σύνδεση εγγραφή
Bilobalide, a constituent of Ginkgo biloba, has neuroprotective properties. Its mechanism of action is unknown but it was recently found to block GABA(A) receptors. The goal of this study was to test the potential role of a GABAergic mechanism for the neuroprotective activity of bilobalide. In rat
Dorsal root reflexes and cutaneous neurogenic inflammation after intradermal injection of capsaicin in rats.
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The role of dorsal root reflexes (DRRs) in acute cutaneous neurogenic inflammation induced by intradermal injection of capsaicin (CAP) was examined in anesthetized rats. Changes in cutaneous blood flow (flare) on the plantar surface of the foot were measured using a laser Doppler flowmeter, and
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- Διαδραστικός χάρτης GPS - ετικέτα βότανα στην τοποθεσία (σύντομα)
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