Greek
Albanian
Arabic
Armenian
Azerbaijani
Belarusian
Bengali
Bosnian
Catalan
Czech
Danish
Deutsch
Dutch
English
Estonian
Finnish
Français
Greek
Haitian Creole
Hebrew
Hindi
Hungarian
Icelandic
Indonesian
Irish
Italian
Japanese
Korean
Latvian
Lithuanian
Macedonian
Mongolian
Norwegian
Persian
Polish
Portuguese
Romanian
Russian
Serbian
Slovak
Slovenian
Spanish
Swahili
Swedish
Turkish
Ukrainian
Vietnamese
Български
中文(简体)
中文(繁體)
hepatitis c/protease
Ο σύνδεσμος αποθηκεύεται στο πρόχειρο
Σελίδα 1 από 214 Αποτελέσματα
Reporter gene system for use in cell-based assessment of inhibitors of the Hepatitis C virus protease
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
TECHNICAL AND INDUSTRIAL APPLICABILITY OF INVENTION
A cell-based assay system in which the detection of reporter gene activity (secreted alkaline phosphatase or SEAP) is dependent upon active Hepatitis C virus (HCV) NS3 protease. The assay system is useful in the in vitro screening, in a mammalian
Reporter gene system for use in cell-based assessment of inhibitors of the hepatitis C virus protease
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
TECHNICAL AND INDUSTRIAL APPLICABILITY OF INVENTION
A cell-based assay system in which the detection of reporter gene activity (secreted alkaline phosphatase or SEAP) is dependent upon active Hepatitis C virus (HCV) NS3 protease. The assay system is useful in the in vitro screening, in a mammalian
Reporter gene system for use in cell-based assessment of inhibitors of the hepatitis C virus protease
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
TECHNICAL AND INDUSTRIAL APPLICABILITY OF INVENTION
A cell-based assay system in which the detection of reporter gene activity (secreted alkaline phosphatase or SEAP) is dependent upon active Hepatitis C virus (HCV) NS3 protease. The assay system is useful in the in vitro screening, in a mammalian
Imidazolidinones and their related derivatives as hepatitis C virus NS3 protease inhibitors
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
FIELD OF THE INVENTION
The present invention relates generally to a novel class of imidazolidinones that are useful as serine protease inhibitors, and more particularly as Hepatitis C virus NS3 protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds
Process for making macrocyclic oximyl hepatitis C protease inhibitors
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
TECHNICAL FIELD
The present invention relates to an improved process for the preparation of macrocyclic compounds that are useful as hepatitis C virus (HCV) protease inhibitor compounds.
BACKGROUND OF THE INVENTION
HCV is the principal cause of non-A, non-B hepatitis and is an increasingly severe
Diaryl peptides as NS3-serine protease inhibitors of hepatitis C virus
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
FIELD OF INVENTION
The present invention relates to novel hepatitis C virus ("HCV") protease inhibitors, pharmaceutical compositions containing one or more such inhibitors, methods of preparing such inhibitors and methods of using such inhibitors to treat hepatitis C and related disorders. This
Peptides and their use as inhibitors of hepatitis C virus ns3 protease
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
FIELD OF THE INVENTION
This invention relates to compounds which can act as inhibitors of the hepatitis C virus (HCV) NS3 protease, to uses of such compounds and to their preparation.
BACKGROUND OF THE INVENTION
The hepatitis C virus (HCV) is the major causative agent of parenterally-transmitted and
Processes for preparing protease inhibitors of hepatitis C virus
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
REFERENCE TO SEQUENCE LISTING SUBMITTED ELECTRONICALLY
The sequence listing of the present application is submitted electronically via EFS-Web as an ASCII formatted sequence listing with a file name "MRLIFD22448USPCT-SEQLIST-09MAY2012.TXT" and a size of 1023 bytes. This sequence listing submitted
Pharmaceutical composition for a hepatitis C viral protease inhibitor
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
FIELD OF THE INVENTION
The present invention relates in general to a pharmaceutical composition of a hepatitis C viral protease inhibitor, methods of using this composition for inhibiting the replication of the hepatitis C virus (HCV) and for the treatment of an HCV infection.
BACKGROUND OF THE
Hepatitis C surrogate virus for testing the activity of hepatitis C virus protease, a recombinant gene and a use thereof
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a hepatitis C virus (HCV), more particularly, is related to a hepatitis C surrogate virus which comprises poliovirus genome, HCV protease and its target site, and is suitable for testing efficacy of anti-HCV drugs
Inhibitors of hepatitis C virus NS3 protease
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
FIELD OF THE INVENTION
The present invention relates generally to a novel class of pyrimidinones that are useful as serine protease inhibitors, and more particularly as Hepatitis C virus NS3 protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds
Peptide inhibitors of hepatitis C virus NS3 protease
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
FIELD OF THE INVENTION
The present invention relates generally to a novel class of peptides, which are useful as serine protease inhibitors, and more particularly as Hepatitis C virus (HCV) NS3 protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds
Pharmaceutical compositions for hepatitis C viral protease inhibitors
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
FIELD OF THE INVENTION
The present invention relates in general to pharmaceutical compositions of hepatitis C viral protease inhibitors, methods of using these compositions for inhibiting the replication of the hepatitis C virus (HCV) and for the treatment of an HCV infection.
BACKGROUND OF THE
Peptide inhibitors of hepatitis C virus NS3 protease
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
TECHNICAL FIELD
This invention relates to compounds which can act as inhibitors of the hepatitis C virus (HCV) NS3 protease, to uses of such compounds and to their preparation.
BACKGROUND ART
The hepatitis C virus (HCV) is the major causative agent of parenterally-transmitted and sporadic non-A,
Hepatitis C virus NS3 protease inhibitors
Μόνο εγγεγραμμένοι χρήστες μπορούν να μεταφράσουν άρθρα
Σύνδεση εγγραφή
FIELD OF THE INVENTION
The present invention relates to macrocyclic compounds that are useful as inhibitors of the hepatitis C virus (HCV) NS3 (non-structural 3) protease, their synthesis, and their use for treating or preventing HCV infection.
BACKGROUND OF THE INVENTION
Hepatitis C viral infection
Η πληρέστερη βάση δεδομένων φαρμακευτικών βοτάνων που υποστηρίζεται από την επιστήμη
- Λειτουργεί σε 55 γλώσσες
- Βοτανικές θεραπείες που υποστηρίζονται από την επιστήμη
- Αναγνώριση βοτάνων με εικόνα
- Διαδραστικός χάρτης GPS - ετικέτα βότανα στην τοποθεσία (σύντομα)
- Διαβάστε επιστημονικές δημοσιεύσεις που σχετίζονται με την αναζήτησή σας
- Αναζήτηση φαρμακευτικών βοτάνων με τα αποτελέσματά τους
- Οργανώστε τα ενδιαφέροντά σας και μείνετε ενημερωμένοι με την έρευνα ειδήσεων, τις κλινικές δοκιμές και τα διπλώματα ευρεσιτεχνίας
Πληκτρολογήστε ένα σύμπτωμα ή μια ασθένεια και διαβάστε για βότανα που μπορεί να βοηθήσουν, πληκτρολογήστε ένα βότανο και δείτε ασθένειες και συμπτώματα κατά των οποίων χρησιμοποιείται.
* Όλες οι πληροφορίες βασίζονται σε δημοσιευμένη επιστημονική έρευνα
