9 Αποτελέσματα
TECHNICAL FIELD
The present invention relates to methods for inhibiting of alpha-glucosidases in subjects. In particular, the invention relates to the use of human pancreatic alpha-amylase inhibitors to reduce starch hydrolysis in subjects and further relates to the treatment of conditions
BACKGROUND OF THE INVENTION
Field of the Invention
The present invention relates generally to medicinal formulations and supplements, and more particularly, to formulations and methods for altering the metabolism of a subject, as well as ameliorating disorders such as cachexia, obesity, diabetes and
BACKGROUND OF THE INVENTION
Field of the Invention
The present invention relates generally to medicinal formulations, and more particularly, to formulations and methods for altering the metabolism of a subject, as well as ameliorating disorders such as obesity, diabetes and insulin
CROSS REFERENCE TO RELATED APPLICATIONS
The present application is a national phase entry under 35 U.S.C. .sctn.371 of International Application No. PCT/JP2006/320611, filed Oct. 17, 2006, published in Japanese, which claims benefit of Japanese Patent Application No. 2005-321108, filed Nov. 4, 2005.
PRIORITY
The present application claims the benefit of Indian Provisional Patent Application No. 1836/CHE/2012 filed on 10 May 2012 and the International Application No. PCT/IB2013/050907 filed on 3 Feb. 2013; the entire disclosure of which is relied on for all purposes and is incorporated into this
BACKGROUND OF THE INVENTION
Proteases are enzymes that cleave proteins at specific peptide bonds. Proteases can be classified into four generic classes: serine, thiol or cysteinyl, acid or aspartyl, and metalloproteases (Cuypers et al., J. Biol. Chem. 1982, 257, 7086. Proteases are essential to a
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to aminoalkyl substituted 5,6,7,8-tetrahydro-9H-pyridino[2,3-b]indole and 5,6,7,8-tetrahydro-9H-pyrimidino[4,5-b]indole derivatives, pharmaceutical compositions containing such compounds and their use in treating
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to aminoalkyl substituted 5,6,7,8-tetrahydro-9H-pyridino[2,3-b]indole and 5,6,7,8-tetrahydro-9H-pyrimidino[4,5-b]indole derivatives, pharmaceutical compositions containing such compounds and their use in treating
FIELD OF THE INVENTION
The invention presented herein is directed to novel imidazopyrimidinyl and imidazopyridinyl derivatives, and to their use as CRF antagonists in the treatment of a variety of neurological and psychiatric disorders.
BACKGROUND OF THE INVENTION
Corticotropin releasing factor