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lactate dehydrogenase/καρκίνος
Ο σύνδεσμος αποθηκεύεται στο πρόχειρο
Σελίδα 1 από 2344 Αποτελέσματα
Measurements of M-subunit lactate dehydrogenase before therapy as an aid to tumour typing in serous effusions.
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Σύνδεση εγγραφή
The levels of lactate dehydrogenase (LDH) isoenzymes were assayed in serous effusions from 111 hospital patients under investigation for cancer. The levels of M-subunit LDH in effusions from patients proven to have cancer were significantly higher than in patients in whom cancer was not proven (p
Lactate dehydrogenase downregulation mediates the inhibitory effect of diallyl trisulfide on proliferation, metastasis, and invasion in triple-negative breast cancer.
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The Warburg effect plays a critical role in tumorigenesis, suggesting that specific agents targeting Warburg effect key proteins may be a promising strategy for cancer therapy. Previous studies have shown that diallyl trisulfide (DATS) inhibits proliferation of breast cancer cells by inducing
[Characteristics of lactate dehydrogenase (LDH) isozyme in human cancers transplanted into nude mice and its application to the evaluation of experimental chemotherapy].
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Human lactate dehydrogenase (LDH) was universally detected and quantified from sera of nude mice bearing human tumors. The patterns of LDH isozyme in sera reflected exactly those in each tumor extract, and remained unchanged over several generations. In 16 human cancers (7 gastric, 4 colorectal, 2
A cancer-associated lactate dehydrogenase is expressed in normal retina.
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An unusual isozyme of lactate dehydrogenase, lactate dehydrogenase k, is found in high concentrations in cultured cells transformed by the Kirsten murine sarcoma virus and in many human cancer tissues. In experiments described here high levels of a lactate dehydrogenase k activity were detected in
[Lactate dehydrogenase and Krebs cycle enzyme activity in rat liver during the growth of transplanted and spontaneous tumors].
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Certain distinctions in the mouse and rat liver responses to transplanted and spontaneous tumours have been discovered at the initial periods of their growth. The most pronounced changes (the mosaic distribution of enzymatic activity in the lobe) are observed in the case of spontaneous tumours.
LDHk, an unusual oxygen-sensitive lactate dehydrogenase expressed in human cancer.
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Σύνδεση εγγραφή
An unusual isozyme of lactate dehydrogenase (LDH; L-lactate:NAD+ oxidoreductase, EC 1.1.1.27), LDHk, has been described in cells transformed by the Kirsten murine sarcoma virus (KiMSV). This isozyme appears to contain one or more subunits encoded by the transforming gene of KiMSV and is readily
[Lactate dehydrogenase isoenzyme in Rous sarcoma and muscle tissue of tumor-bearing hens].
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The isoenzymic spectrum and lactate dehydrogenase activity (LDH) were studied in tumor and pectoral muscle of both chicken and adult hens on the 6th, 10th and 15th day after their infection with the Rous sarcoma virus. On the 14th day, unlike the muscles of intact hens, in the tumour the content of
[Lactate level in the tissues of animals with a tumor administered oxythiamine and the properties of lactate dehydrogenase].
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Content of lactate in blood, liver and kidney tissues, skeletal muscle and in tumor tissue as well as some properties of lactate dehydrogenase (LDH), isolated from liver tissue, were studied in three groups of rats - intact rats, the tumor-bearing animals with sarcoma S-45 and the tumor-bearing rats
Effect of Caffeine on Serum Tumour Necrosis Factor Alpha and Lactate Dehydrogenase in Wistar Rats Exposed to Cerebral Ischaemia-reperfusion Injury.
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Caffeine is known to confer neuro-protection via A1 and A2A adenosine receptor antagonism in which adenosine neuro-modulates excitotoxic release of glutamate. Currently, it is unclear whether caffeine modulates inflammation in ischaemic stroke model. The present study examined effects of caffeine
Impact of cyclometalated ruthenium(II) complexes on lactate dehydrogenase activity and cytotoxicity in gastric and colon cancer cells.
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Lactate dehydrogenase (LDH) is a redox enzyme often overexpressed in cancer cells allowing their survival in stressful metabolic tumor environment. Ruthenium(II) complexes have been shown to impact on the activity of purified horseradish peroxidase and glucose oxidase but the physiological relevance
The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B.
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Previously, we showed that drs contributes to suppression of malignant tumor formation in drs-knockout (KO) mice. In this study, we demonstrate the regulation of glucose metabolism by drs using comparisons of drs-KO and wild-type (WT) mouse embryonic fibroblasts (MEFs). Extracellular acidification,
Lactate dehydrogenase as a prognostic factor for survival time of terminally ill cancer patients: a preliminary study.
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This study evaluated lactate dehydrogenase (LDH) as a prognostic factor for survival time in terminal cancer patients. We prospectively followed 93 consecutive inpatients with terminal cancer in one general hospital. Cox's proportional hazard model was used to adjust the influence of some clinical
Elevation of serum lactate dehydrogenase at posterior reversible encephalopathy syndrome onset in chemotherapy-treated cancer patients.
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The pathophysiology of posterior reversible encephalopathy syndrome (PRES) is incompletely understood; however, an underlying state of immune dysregulation and endothelial dysfunction has been proposed. We examined alterations of serum lactate dehydrogenase (LDH), a marker of endothelial
Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: involvement of the Akt-mTOR signaling pathway.
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Cancer cells produce a substantial amount of energy through aerobic glycolysis even in the presence of adequate oxygen. Lactate dehydrogenase (LDH), a key regulator of glycolysis, reversibly catalyzes the conversion of pyruvate to lactate. Recently, oxamate, an inhibitor of LDH, has been shown to be
N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation.
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Current cancer research is being increasingly focused on the study of distinctive characters of tumour metabolism, resulting in a switch from oxidative phosphorylation to glycolysis (Warburg effect). Isoform 5 of human lactate dehydrogenase (hLDH5), which catalyzes the final step in the glycolytic
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