Σελίδα 1 από 136 Αποτελέσματα
The critical role of α1-glycine receptor (α1-GLYRs) in pathological conditions such as epilepsy is well known. In the present study, structure-activity relations for a series of phenylalanine derivatives carrying selected hydrogen bond acceptors were investigated on the functional properties of
The effects of excessive doses of phenylalanine on seizure susceptibility were examined in animal models in the past, primarily because of their relevance to phenylketonuria. It was thought that such effects might involve brain monoaminergic mechanisms. Recently, this issue has been pursued with a
Reduced audiogenic seizure susceptibility in dilute mice was associated with enhancement of phenylalanine hydroxylase activity, previously reported as low in dilute mice. Though nutritional changes complicate the interpretation, evidence exists for a mutation linked with dilute which modifies
The degree of audiogenic seizure was measured in DBA/2J (phenylalanine hydroxylase deficient) mice as a function of dietary phenylalanine (Phe) and injected 5-hydroxytryptophan (5-HTP), the precursor of serotonin (5-HT). Phe was shown to exacerbate seizures significantly, and seizure severity was
Male rats were treated by oral intubation with tyrosine (Tyr), at doses of 0.5 and 1.0 g/kg body weight, alone or together with 1 g aspartame (APM)/kg body weight, or an equivalent dose of phenylalanine (Phe; 0.5 g/kg body weight); the effects on seizures induced by an effective dose of metrazol
Oral administration of the artificial sweetener aspartame, 1 g/kg, or of an equimolar dose of its metabolite phenylalanine, to fasted rats 1 hour before slow i.v. infusion of theophylline until the onset of maximal seizures had no significant effect on the total dose and the serum and cerebrospinal
OBJECTIVE
Abnormal glutamatergic activity is implicated in neurologic and neuropsychiatric disorders. Selective glutamate receptor antagonists were highly effective in animal models of stroke and seizures but failed in further clinical development because of serious side effects, including an almost
Convulsive responsiveness of O'Grady mice, inbred for susceptibility to audiogenic seizures, was decreased following treatment with the serotonin precursor, 5-hydroxytryptophan, or serotonin depletor, p-chlorophenylalanine. Neither agent exerted any antagonistic or synergistic action on the effect
Evidence of genetic factors in seizure disorders by examination of plasma amino acid concentrations in multiply affected sibships was investigated. The strategy of multiply affected sibship ascertainment was used to reduce heterogeneity as one of several potential sources of variation in
The purpose of this paper was to study the relationship between different neurotransmitter systems and seizure susceptibility in Mongolian gerbils with genetically determined epilepsy. In these animals, generalized tonic-clonic seizures were induced by stimulation with a blast of compressed air. A
The effects of large doses of L-phenylalanine and of aspartame on seizure susceptibility and severity have been assessed in baboons Papio papio from Senegal which show photosensitive epileptic responses similar to primary generalised epilepsy in man. L-Phenylalanine, 50, 150 or 450 mg/kg, or