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Σελίδα 1 από 175 Αποτελέσματα
Anti-fatigue and anti-oxidant activities of oyster (Ostrea rivularis) hydrolysate prepared by compound protease.
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Σύνδεση εγγραφή
Oyster, which is rich in protein and widely used as a marine traditional Chinese medicine, was believed to have good curative effects in health care and on chronic diseases. This study was designed to evaluate the anti-fatigue and anti-oxidant effects of oyster hydrolysate. Oyster meat (OM) was
Mechanisms of excitation-contraction uncoupling relevant to activity-induced muscle fatigue.
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If the free [Ca2+] in the cytoplasm of a skeletal muscle fiber is raised substantially for a period of seconds to minutes or to high levels just briefly, it leads to disruption of the normal excitation-contraction (E-C) coupling process and a consequent long-lasting decrease in force production. It
Telaprevir: an oral protease inhibitor for hepatitis C virus infection.
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OBJECTIVE
The pharmacology, pharmacokinetics, pharmacodynamics, clinical efficacy, safety, drug interactions, viral drug resistance, dosage and administration, and place in therapy of telaprevir are reviewed.
CONCLUSIONS
Telaprevir is an oral NS3/4A protease inhibitor that was recently approved by
Cohesion fatigue induces chromatid separation in cells delayed at metaphase.
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BACKGROUND
Chromosome instability is thought to be a major contributor to cancer malignancy and birth defects. For balanced chromosome segregation in mitosis, kinetochores on sister chromatids bind and pull on microtubules emanating from opposite spindle poles. This tension contributes to the
Bioimpedance analysis and HIV-related fatigue.
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Although various physiological and psychological causes of fatigue in HIV-positive persons have been proposed, it is still not well understood. Bioimpedance analysis has proved to be an easily used, non-invasive measurement of body composition and cellular integrity. This study, looking at whether
Mechanisms underlying the slow recovery of force after fatigue: importance of intracellular calcium.
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Recovery of force production after an intense bout of activity may sometimes take several days, especially at low activation frequencies ('low frequency fatigue'). This slow recovery can also be observed in isolated muscle and single muscle fibres. The origin of the force deficit is failure of
Regulation of skeletal muscle myofibrillar protein degradation: relationships to fatigue and exercise.
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Σύνδεση εγγραφή
1. Exercise results in large alterations in cellular metabolic homeostasis and protein turnovers. Exhaustive exercise (as well as starvation, dystrophy, motor nerve disease) results in myofibrillar degradation and has been associated with the decreased force generating capabilities of muscle at
Skeletal muscle calcium-activated neutral protease (calpain) with exercise.
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The purpose of this study was to investigate whether exercise could induce calpain activation by altering the Ca2+ required for half-maximal activity (pCa50) and/or susceptibility of digestible muscle protein substrates. Rats (225 g) were assigned to control, exercise (25 m/min, 0% grade), and 24-h
Removal Torque and Biofilm Accumulation at Two Dental Implant-Abutment Joints After Fatigue.
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OBJECTIVE
The aim of this study was to evaluate the removal torque and in vitro biofilm penetration at Morse taper and hexagonal implant-abutment joints after fatigue tests.
METHODS
Sixty dental implants were divided into two groups: (1) Morse taper and (2) external hexagon implant-abutment systems.
Ribonuclease L proteolysis in peripheral blood mononuclear cells of chronic fatigue syndrome patients.
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A 37-kDa binding polypeptide accumulates in peripheral blood mononuclear cell (PBMC) extracts from chronic fatigue syndrome (CFS) patients and is being considered as a potential diagnostic marker (De Meirleir, K., Bisbal, C., Campine, I., De Becker, P., Salehzada, T., Demettre, E., and Lebleu, B.
Contractile properties of slow and fast skeletal muscles from protease activated receptor-1 null mice.
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BACKGROUND
Protease-activated receptors (PARs) may play a role in skeletal muscle development. We compared the contractile properties of slow-twitch soleus muscles and fast-twitch extensor digitorum longus (EDL) muscles from PAR-1 null and littermate control mice.
METHODS
Contractile function was
Membrane excitability and excitation-contraction uncoupling in muscle fatigue.
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High-frequency tetanic stimulation is associated with an increase in extracellular and T-tubular K(+) and changes of Na(+) and Cl(-) concentrations, membrane depolarization as well as inactivation of voltage-gated Na(+) channels. These alterations are expected to lead to fiber inexcitability, which
The role of elevations in intracellular [Ca2+] in the development of low frequency fatigue in mouse single muscle fibres.
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1. Intracellular free calcium concentration ([Ca2+]i) and force were measured in isolated single skeletal muscle fibres from mice. The aim was to determine the extent to which elevations in [Ca2+]i during various stimulation protocols affected subsequent muscle performance. 2. A protocol of repeated
Boceprevir: a protease inhibitor for the treatment of chronic hepatitis C.
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OBJECTIVE
To review the pharmacology, pharmacokinetics, safety, and efficacy of boceprevir, a novel oral hepatitis C virus (HCV) nonstructural 3 (NS3) protease inhibitor for the treatment of chronic HCV infection, specifically, genotype 1.
METHODS
A literature search was conducted through MEDLINE
The Evaluation of Medication Adherence in Patients Infected With HCV Receiving Protease Inhibitors: A Pilot Study.
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Adherence to treatment is essential for hepatitis C cure. Studies show the complexity of the treatment due to side effects, many pills, and rigor in the schedules. The aim of this study was to evaluate the adherence to treatment with protease inhibitor in patients with hepatitis C. It is a
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