Effects of a Resistance Training Period on Blood Pressure of Hypertensive Elderlies: Influence of the Polymorphism of the Angiotensin Converting Enzyme
Keywords
Abstract
Description
To investigate the chronic effects of resistance training on blood pressure and biochemical exams in elderly, 135 hypertensive elderlies were divided into 2 groups: trained and control. The trained group was submitted to a resistance training period. Before the 16 weeks ACE gene was genotyped (PCR). Before and after 16 weeks, blood pressure (ambulatory), HDL-cholesterol, Total cholesterol, Glycemia, Triacylglycerol (colorimetric assay) and plasminogen activator inhibition (PAI-1), intercellular adhesion molecule (ICAM-1), vascular endothelial cell adhesion molecule (VCAM-1), Adiponectin, tumor necrosis factor alpha (TNF-alpha), C Reactive Protein, Angiotensin II, Angiotensin Converting Enzyme, Angiotensin 1-7, (ELISA assay) were measured.
Dates
| Last Verified: | 09/30/2013 |
| First Submitted: | 10/08/2013 |
| Estimated Enrollment Submitted: | 10/10/2013 |
| First Posted: | 10/15/2013 |
| Last Update Submitted: | 10/10/2013 |
| Last Update Posted: | 10/15/2013 |
| Actual Study Start Date: | 03/31/2010 |
| Estimated Primary Completion Date: | 03/31/2013 |
| Estimated Study Completion Date: | 03/31/2013 |
Condition or disease
Intervention/treatment
Behavioral: Resistance training
Phase
Arm Groups
| Arm | Intervention/treatment |
|---|---|
| Experimental: Resistance training Resistance training performed three times at week for 16 weeks, in 8 exercises for the main muscles, the protocol of 3 sets of 10 repetitions with intensity of 50% of 1 maximum repetition (MR). | Behavioral: Resistance training Resistance training performed three times at week for 16 weeks, in 8 exercises for the main muscles, the protocol of 3 sets of 10 repetitions with intensity of 50% of 1 maximum repetition (MR). |
| No Intervention: Control |
Eligibility Criteria
| Ages Eligible for Study | 60 Years To 60 Years |
| Sexes Eligible for Study | All |
| Accepts Healthy Volunteers | Yes |
| Criteria | Inclusion Criteria: - Hypertensives - Age 60 to 85 years - Nonactive Exclusion Criteria: - Orthopedic problems or other problem that prevented the exercises - Change in drug treatment during protocol - Absence in more than 25% of the exercise sessions |
Outcome
Primary Outcome Measures
1. Blood Pressure [16 weeks]
Secondary Outcome Measures
1. HDL-cholesterol [16 weeks]
2. Total Cholesterol [16 weeks]
3. Glycemia [16 weeks]
4. Triacylglycerol [16 weeks]
5. PAI-1 [16 weeks]
6. ICAM-1 [16 weeks]
7. VCAM-1 [16 weeks]
8. Adiponectin [16 weeks]
9. TNF alpha [16 weeks]
10. C Reactive Protein [16 weeks]
11. Angiotensin II [16 weeks]
12. Angiotensin Converting Enzyme [16 weeks]
13. Angiotensin 1-7 [16 weeks]
