Coagulopathy in COVID19 - A Multi-Centre Observational Study in UK
Keywords
Abstract
Dates
Last Verified: | 04/30/2020 |
First Submitted: | 05/25/2020 |
Estimated Enrollment Submitted: | 05/25/2020 |
First Posted: | 05/27/2020 |
Last Update Submitted: | 05/27/2020 |
Last Update Posted: | 05/31/2020 |
Actual Study Start Date: | 05/20/2020 |
Estimated Primary Completion Date: | 04/19/2021 |
Estimated Study Completion Date: | 06/19/2021 |
Condition or disease
Intervention/treatment
Other: Non-interventional
Phase
Eligibility Criteria
Ages Eligible for Study | 18 Years To 18 Years |
Sexes Eligible for Study | All |
Sampling method | Non-Probability Sample |
Accepts Healthy Volunteers | No |
Criteria | Inclusion Criteria: - Adult patients (>18 years) admitted hospitals with COVID 19 infection (COVID RNA+ +/- radiological change +/- clinical suspicion in absence of RNA) Exclusion Criteria: - No exclusions |
Outcome
Primary Outcome Measures
1. Prevalence and characteristics of coagulation abnormalities and their predictive value for respiratory failure requiring ventilation, multiorgan failure and death in patients presenting with COVID 19 infection [12 months]
Secondary Outcome Measures
1. Incidence of respiratory failure requiring CPAP or mechanical ventilation [12 months]
2. Incidence of thrombosis (clinical or radiological diagnosis) including thrombosis within 90 days after hospital admission (hospital associated thrombosis) 4. Incidence of minor bleeding 5. Heparin induced thrombocytopenia 6. Acute coronary syndrome [12 months]
3. Incidence of major bleeding 8. Multiorgan failure 9. Development of DIC 10. Duration of hospital stay (days) 11. Hospital mortality [12 months]
4. Incidence of clinically relevant non-major bleeding [12 months]
5. Incidence of Heparin induced thrombocytopenia [12 months]
6. Incidence of Acute coronary syndrome [12 months]
7. Incidence of renal failure requiring renal replacement therapy [12 months]
8. Incidence of Multiorgan failure [12 months]
9. Incidence of Development of DIC [12 months]
10. Duration of hospital stay (days) [12 months]
11. Hospital mortality [12 months]