Efficacy of Vitamin D in Colorectal Cancer Chemoprevention
Keywords
Abstract
Description
Patients will be offered participation in this study at the time of their regularly scheduled visit to the UIC Colorectal Cancer Screening Clinic. Those agreeing will have indicated their understanding that participation will be conditional upon their having 10+ ACF at the time of their screening colonoscopy. If at screening colonoscopy 10+ ACF are found patients will:
- undergo 3 endoscopic mucosal biopsies of the distal colon; and
- undergo a blood draw from an i.v. already in place for sedative-narcotic administration for serum 25(OH)D3 and serum ionized calcium; and
- be given either placebo or calcifediol and instructed to take daily for 6 months.
- provide urine for calcium/creatine spot ratio.
At 7 and 14 days after the screening colonoscopy patients will be called on the telephone by the clinical research nurse assigned to this study to follow-up and note 25(OH)D3 (calcifediol) toxicity, if any (note that toxicity has not been described except in the case of overdose). Signs specifically looked for will include: headache, increased urination, nausea, vomiting, abdominal pain, weakness, constipation, and anorexia. If present, patient will be advised to present immediately to the UIC GCRC for physical and serological evaluation.
At 30, 90 and 120 days the patient will have agreed to present to the GCRC clinic for:
- Capsule retrieval/count (80% compliance will be required to remain in study); and
- Detailed history and physical, focusing specifically on signs and symptoms of hypercalcemia.
- At day 90 only - provide urine for calcium/creatine spot ratio.
Evidence on exam, or laboratory, of hypercalcemia will result in an adverse event reporting and immediate patient discharge from this study. Signs specifically looked for include: headache, increased urination, nausea, vomiting, abdominal pain, weakness, constipation, and anorexia.
At 180 days the patient will have agreed to undergo:
- Repeat endoscopic exam limited to the recto-sigmoid colon, also known as a "flexible sigmoidoscopy"; and
- repeat blood draw for serum 25(OH)D3 and serum ionized calcium
Dates
Last Verified: | 03/31/2012 |
First Submitted: | 03/29/2012 |
Estimated Enrollment Submitted: | 04/04/2012 |
First Posted: | 04/09/2012 |
Last Update Submitted: | 04/04/2012 |
Last Update Posted: | 04/09/2012 |
Actual Study Start Date: | 03/31/2008 |
Estimated Primary Completion Date: | 09/30/2011 |
Estimated Study Completion Date: | 09/30/2011 |
Condition or disease
Intervention/treatment
Drug: Vitamin D3 (cholecalciferol)
Drug: Placebo
Phase
Arm Groups
Arm | Intervention/treatment |
---|---|
Placebo Comparator: Placebo Some participants were given a placebo pill to take daily for the length of the study. The placebo patients were used as a control group to compare against those taking the Vitamin D supplement. | Drug: Placebo One capsule per day for six months |
Experimental: Vitamin D3 (cholecalciferol) Other participants were administered Vitamin D3 (cholecalciferol) for the six month study duration to determine if it would decrease the number of aberrant crypt foci in the colon as compared to the baseline number. | Drug: Vitamin D3 (cholecalciferol) One capsule per day for six months |
Eligibility Criteria
Ages Eligible for Study | 50 Years To 50 Years |
Sexes Eligible for Study | All |
Accepts Healthy Volunteers | Yes |
Criteria | Inclusion Criteria: - All non-pregnant patients 50 years of age or older with 10 or more ACFs. Exclusion Criteria: - The following will be specifically looked for, and result in patients not being eligible for study enrollment: - Use of non-steroidal anti-inflammatory drugs or glucocorticosteroids within 60 days of study entry. - History of chronic IBD or prior pelvic radiation (inflammation distorts crypt pattern). - Intake of any vitamin D or calcium supplements within 60 days of study entry. - Patients with increased bleeding risk from biopsy protocol (i.e. renal failure, decompensated cirrhosis, blood dyscrasia |
Outcome
Primary Outcome Measures
1. Reduction in ACF biomarkers [6 months]