Spectrum of Serum Sodium Disturbances in Patients With Non-sellar/Suprasellar Supratentorial Tumors
Keywords
Abstract
Description
Disorders of sodium and water balance are one of the commonly encountered problems while managing patients with neurological diseases. Managing such problems are challenging because the pathophysiology behind these disorders are complex and poorly understood and treatment of the injured brain itself can contribute to, and complicate the diagnosis of sodium disorders. Serum sodium disturbance can manifest as hypernatremia or hyponatremia. Hypernatremia usually occurs in the diabetes insipidus syndrome, whereas hyponatremia develops as a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) or cerebral salt-wasting syndrome (CSWS).
Because of the cerebral effects of hyponatremia, neurosurgical patients are at increased risk of complications including severe cerebral edema, mental status changes, seizures, vasospasm, and death.
Though the problem of hyponatremia has been addressed in patients with different brain pathologies, this has not been studied in patients with non-sellar/suprasellar supratentorial tumors. This study was envisioned to quantify the incidence and magnitude of hyponatremia in this patient population and their subsequent neurological morbidity and mortality.
Dates
| Last Verified: | 05/31/2018 |
| First Submitted: | 06/13/2018 |
| Estimated Enrollment Submitted: | 06/24/2018 |
| First Posted: | 06/25/2018 |
| Last Update Submitted: | 06/24/2018 |
| Last Update Posted: | 06/25/2018 |
| Actual Study Start Date: | 12/14/2013 |
| Estimated Primary Completion Date: | 04/29/2014 |
| Estimated Study Completion Date: | 04/29/2014 |
Condition or disease
Intervention/treatment
Diagnostic Test: Serum Sodium
Phase
Arm Groups
| Arm | Intervention/treatment |
|---|---|
| Retrospective Cohort Supratentorial/Suprasellar brain tumor patients with Glasgow Coma Score > 3 at time of admission. | |
| Prospective Cohort Supratentorial/Suprasellar brain tumor patients with Glasgow Coma Score > 3 at time of recruitment. |
Eligibility Criteria
| Ages Eligible for Study | 18 Years To 18 Years |
| Sexes Eligible for Study | All |
| Sampling method | Non-Probability Sample |
| Accepts Healthy Volunteers | Yes |
| Criteria | Inclusion Criteria: Patients undergoing surgical management for supratentorial/suprasellar tumors. Exclusion Criteria: Glasgow Coma Score (GCS) <4. |
Outcome
Primary Outcome Measures
1. Mortality [From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission.]
Secondary Outcome Measures
1. Duration of hospital stay [From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission.]
2. Rate of admission in intensive care unit. [From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission.]
3. Neurological deficits [From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission.]
4. Seizures [From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission.]
