Holoprosencephaly (HPE) is a cephalic disorder in which the prosencephalon (the forebrain of the embryo) fails to develop into two hemispheres. Normally, the forebrain is formed and the face begins to develop in the fifth and sixth weeks of human pregnancy. The condition also occurs in other species.
The condition can be mild or severe. Most cases are not compatible with life and result in fetal death in utero.When the embryo's forebrain does not divide to form bilateral cerebral hemispheres (the ...Read more in Wikipedia
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