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Planta Medica 2009-Jan

A promising anticancer and antimalarial component from the leaves of Bidens pilosa.

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Priyanka Kumari
Kanak Misra
Brijesh Singh Sisodia
Uzma Faridi
Suchita Srivastava
Suiab Luqman
Mahendra Pandurang Darokar
Arvind Singh Negi
Madan Mohan Gupta
Subhash Chandra Singh

Keywords

Abstract

Bidens pilosa is used in folk medicine for various applications due to the presence of polyacetylenes, flavonoids, terpenoids, phenylpropanoids and others. Bioactivity-guided fractionation of different extracts of B. pilosa leaf showed potential in vitro anticancer and antimalarial activity and led to the identification of a potential marker compound, phenyl-1,3,5-heptatriyne. Erythrocyte osmotic fragility experiments revealed the various extracts as well as the marker component's toxicity profiles on normal blood cells.

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