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Bulletin of Experimental Biology and Medicine 2014-Jan

Adaptogenic effects of dihydroquercetin-chitosan composition during modeling of acute hypoxia.

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E I Murach
I A Baranov
E I Erlykina
A S Koryagin
A E Mochalova
L A Smirnova

Keywords

Abstract

The course of preventive oral treatment with a dihydroquercetin-chitosan composition produced a strong antihypoxic effect under conditions of experimental hypobaric hypoxia (arbitrary altitude 12,000 m). The lactate/pyruvate ratio in composition-receiving rats was much lower than in hypoxic animals (by 83%), but higher than in intact specimens (by 29%). The composition of chitosan and dihydroquercetin also possessed a strong antioxidant activity.

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