Cancer Letters 1983-Jul
Alteration of phenotype of 'regressor' avian sarcoma cells following treatment with phorbol ester.
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Abstract
Tumor cells which are cultured from the regressor phase of avian sarcoma virus (ASV)-induced tumor growth are deficient with respect to ability to produce progeny transforming virus. In addition, such cells are relatively unreactive with anti-viral antibody and are unable to elaborate, into the medium, antigens which are stimulatory to the sensitized lymphocytes of virus-injected hosts. These deficits can be overcome by treatment of the cells with the tumor promoter, phorbol myristate acetate (PMA).