Biochemical and Biophysical Research Communications 1984-Aug

Alteration of poly(ADP-ribose) metabolism by hyperthermia.

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H Juarez-Salinas

G Duran-Torres

M K Jacobson

ARTICLE: 6089782

BioSeek: 6089782

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Abstract

The intracellular levels of poly(ADP-ribose) in cultured mouse cells were increased in response to hyperthermic treatment (43 degrees C). When hyperthermia was combined with other stressful treatments such as with ethanol and/or an alkylating agent, a dramatic synergistic increase in polymer levels was observed. The effect of hyperthermia did not appear to be related to the presence of DNA strand breaks. A possible involvement of poly(ADP-ribose) metabolism in the general cellular response to environmental stress is suggested.

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Alteration of poly(ADP-ribose) metabolism by hyperthermia.

Keywords

ribose

fever

Abstract

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