Medical Letter on Drugs and Therapeutics 2005-Jan
Apomorphine (Apokyn) for advanced Parkinson's Disease.
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Abstract
Apomorphine (Apokyn) is now available for rescue treatment of "off" episodes in patients with advanced Parkinson's disease. It must be injected subcutaneously. Apomorphine in a variety of formulations has been used in Europe for many years. Like other dopamine agonists it can cause nausea and vomiting, orthostatic hypotension, drowsiness, "sleep attacks" and dyskinesias. It should be taken initially with an antiemetic to avoid nausea and vomiting.