Journal of Medicinal Chemistry 2007-Apr

(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors.

Only registered users can translate articles

The link is saved to the clipboard

Kyeong Lee

Jeong Hyung Lee

Shanthaveerappa K Boovanahalli

Yinglan Jin

Mijeoung Lee

Xuejun Jin

Jin Hwan Kim

Young-Soo Hong

Jung Joon Lee

ARTICLE: 17328532

DOI: 10.1021/jm0610292

BioSeek: 17328532

Keywords

Abstract

Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1alpha protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.

Join our facebook page

Herbal & Natural Medicine

The most complete medicinal herbs database backed by science

Works in 55 languages
Herbal cures backed by science
Herbs recognition by image
Interactive GPS map - tag herbs on location (coming soon)
Read scientific publications related to your search
Search medicinal herbs by their effects
Organize your interests and stay up do date with the news research, clinical trials and patents

Type a symptom or a disease and read about herbs that might help, type a herb and see diseases and symptoms it is used against.
*All information is based on published scientific research