Chemical Communications 2017-Sep

Biotin-tagged platinum(iv) complexes as targeted cytostatic agents against breast cancer cells.

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Nafees Muhammad

Nasreen Sadia

Chengcheng Zhu

Cheng Luo

Zijian Guo

Xiaoyong Wang

ARTICLE: 28831477

DOI: 10.1039/c7cc05311h

BioSeek: 28831477

Keywords

Abstract

A biotin-guided platinumIV complex is highly cytotoxic against breast cancer cells but hypotoxic against mammary epithelial cells. The mono-biotinylated PtIV complex is superior to the di-biotinylated one and hence a promising drug candidate for the targeted therapy of breast cancer.

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Biotin-tagged platinum(iv) complexes as targeted cytostatic agents against breast cancer cells.

Keywords

breast neoplasms

neoplasms

biotin

Abstract

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