OncoImmunology 2013-Mar
COX2 regulation of breast cancer bone metastasis.
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Keywords
Abstract
High expression levels of cyclooxygenase 2 expression and infiltration by regulatory T cells (Tregs) are often associated with tumor progression. We have recently reported a prostaglandin E2 (PGE2)-dependent recruitment of Tregs to the tumor, suggesting that targeting specific PGE2 receptors may constitute a valuable approach to ablate the immuno-editing that occurs along with disease progression.