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Cardiovascular & hematological agents in medicinal chemistry 2013-Sep

Cardioprotective effect of resveratrol and resveratroloside.

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Sergey E Naumenko
Tatiana V Latysheva
Michael A Gilinsky
Artem D Rogachev
Nina I Komarova
Nariman F Salakhutdinov
Genrikh A Tolstikov

Keywords

Abstract

Cardioprotective effect of resveratrol and resveratroloside was determined in ischemia-reperfusion experiments on rats. It was found that single intraperitoneal administration of any compound (10 mg/kg) followed by 30-min ischemia and 120-min reperfusion resulted in statistically significant decrease of myocardial infarct area (55.0±4.0% for control group; 40.7±4.4% for the group 1 received resveratrol; 41.6±4.8% for the group 2 received resveratroloside). The cardioprotective effect of resveratroloside was detected for the first time.

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