[Change in the anti-inflammatory activity of nonsteroidal antiphlogistics in conditions of acute hypoxic hypoxia].

It has been shown on animals with experimental histamine edema under acute hypoxic hypoxia that anti-inflammatory properties of the known non-steroidal antiphlogistics and new derivatives of fumaric acid heterylamides administered in a dose of 10% of the LD50 underwent changes. At "altitudes" of 5000 and 10000 m a high enough anti-inflammatory activity was preserved by the drugs that, apart from an anti-exudative action, produced an antihypoxic one. The other non-steroidal anti-inflammatory drugs under study demonstrated either a lowered activity or completely lost it, depending on the "altitude".