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Journal of Natural Products 2003-Mar

Chemical constituents of Calophyllum brasiliense. 2. Structure of three new coumarins and cancer chemopreventive activity of 4-substituted coumarins.

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Chihiro Ito
Masataka Itoigawa
Yoshitaka Mishina
Valdir Cechinel Filho
Fumio Enjo
Harukuni Tokuda
Hoyoku Nishino
Hiroshi Furukawa

Keywords

Abstract

Continuing our search for cancer chemopreventive agents from natural sources, we examined constituents of the stem bark of Calophyllum brasiliense. Three new 4-substituted coumarins named brasimarins A (2), B (3), and C (4) were isolated and characterized, along with 11 known coumarins belonging to the calanolides or inophyllums. We also discuss the inhibitory effects of these coumarins on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells.

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