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Zeitschrift für Naturforschung - Section C Journal of Biosciences

Cytotoxic xanthones from Garcinia penangiana Pierre.

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Md Lip Jabit
Rozida Khalid
Faridah Abas
Khozirah Shaari
Lim Siang Hui
Johnson Stanslas
Nordin H Lajis

Keywords

Abstract

Two new xanthones, characterized as 4-(1,1-dimethylprop-2-enyl)-1,3,5,8-tetrahydroxyxanthone (1) and penangianaxanthone (2), with three known xanthones, cudratricusxanthone H (3), macluraxanthone C (4) and gerontoxanthone C (5), as well as friedelin and stigmasterol were isolated from the leaves of Garcinia penangiana. Their structures were elucidated by analysis of spectroscopic data and comparison of the NMR data with the literature ones. Significant cytotoxicity against DU-145, MCF-7 and NCI-H460 cancer cell lines was demonstrated by compounds 1-5, with IC50 values ranging from 3.5 to 72.8 microM.

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