Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie 1983
[Demonstration and partial purification of a convulsant from Cnestis glabra (Connaracea): effect on cells in culture].
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Abstract
A dialysable and thermostable compound was partially purified from Cnestis glabra (Connaracea) seeds. It is insoluble in organic solvents. At a dose corresponding to 0.5 g of seeds it has a lethal effect on mice after convulsive attacks. Sodium dipropylacetate, an anticonvulsive agent prevents the convulsions but not the death of the animals. The toxic compound inhibits protein synthesis in a rabbit reticulocyte lysate and in hepatoma tissue culture; moreover in the cell culture, the incorporation of thymidine into DNA is inhibited.