Annals of the New York Academy of Sciences 2000-May
Effect of leptin in platelet and endothelial cells. Obesity and arterial thrombosis.
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Abstract
We demonstrated that leptin showed effects on both platelets and endothelial cells through its functional receptor. These effects are the vector to inducing thrombotic tendency. Leptin concentrations used in our experiments correspond to that of leptin in the circulation of obese individuals. Thus we suggest that increased leptin may act as a risk factor for thrombosis in obese individuals.
